HYPERCALCEMIA CAUSED BY ORAL NEOPLASIA
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Hypercalcemia in dogs can be caused by a variety of diseases, but this one is surely one of the less common differentials: an oral functional keratinizing ameloblastoma which caused a high serum parathyroid hormone-related peptide and consecutive hypercalcemia. A very interesting case - telling veterinarians they should always examine the oral cavity in dogs with hypercalcemia!
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This case report describes a 6-year-old dog with oral ameloblastoma and hypercalcaemia.
Serum parathyroid hormone-related peptide (PTH-rp) levels were high. No other cause for hypercalcaemia was found.
The hypercalcaemia resolved after hemimandibulectomy.
We are not aware of the previous description of canine oral ameloblastoma and hypercalcaemia mediated by PTH-rp.
This case report suggests that PTH-rp stimulation of the PTH receptor may result in hypercalcaemia in dogs with oral ameloblastoma or other odontogenic neoplasms.
Source: Dhaliwal, R. S. & Tang, K. N. (2005)
Parathyroid hormone-related peptide and hypercalcaemia in a dog with functional keratinizing ameloblastoma. In: Veterinary and Comparative Oncology 3 (2), 98-100.
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