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Research program for a NCL disease on the University of Missouri
Tibetan terriers are a breed that is known to be affected by neuronal ceroid lipofuscinosis (NCL), a neurologic disease with a human equivalent called Batten disease. The owned dogs are contributing to a canine DNA bank for research on the currently incurable, fatal disease. The American Kennel Club Canine Health Foundation, the Batten Disease Support and Research Association, and Research to Prevent Blindness, Inc. has funded the research program.


NCL diseases are inherited, making the purebred terriers ideal since the genes can be traced back many generations.

Dr. Martin Katz, DVM, MD, says he believes terriers can help researchers better understand the pathology of the disease and find a treatment for both species.

The normal canine genome, which has been sequenced, is compared to the DNA of the affected and unaffected Tibetan Terriers to pinpoint the NCL mutation in this breed, researchers say.

Katz was able to eliminate mutations in known NCL genes as the cause of the Tibetan Terrier disease.

The next step is the identification of the NCL mutation in Tibetan Terriers. This now requires that the mutant gene be located through a mapping or linkage analysis. The analysis involves a comparison of the DNA from a large number of affected dogs with the DNA of their parents and affected littermates, authorities say.

Once the NCL mutation in Tibetan Terriers has been identified, a blood test for the mutation can be performed. This will enable veterinarians to screen dogs prior to giving a clean bill of health for breeding; preventing additional affected dogs in the future. Identification of the Tibetan Terrier NCL mutation also will make it possible to determine whether humans with NCL have the mutations in the corresponding human gene.



Source: www.dvmnewsmagazine.com/dvm/









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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breedâ€specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breedâ€specific RIs, where appropriate.

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