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Do hydromorphone hydrochloride and acepromazine affect the dog´s eye?
17 dogs without clinically relevant ocular abnormalities were checked for changes in intraocular pressure (IOP) and pupil size (PS) following intramuscular administration of hydromorphone hydrochloride and acepromazine.


Measurements of IOP and PS were obtained and the dogs were injected intramuscularly with hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg). Measurements of IOP and PS were repeated 10 min and 25 min later.

Though a decreasing trend in IOP values was demonstrated, no significant difference was noted in IOP from the initial examination to examination following intramuscular administration of hydromorphone and acepromazine. Significant miosis was present in 16 of 17 dogs at 10 min and 25 min following administration of hydromorphone and acepromazine.

Hydromorphone (0.04-0.08 mg/kg) and acepromazine (0.04 mg/kg) cause significant miosis in dogs at 10 and 25 min following intramuscular administration.


Source: Stephan, D.D., Vestre, W. A., Stiles, J., Krohne, S.(2003): Changes in intraocular pressure and pupil size following intramuscular administration of hydromorphone hydrochloride and acepromazine in clinically normal dogs. In: Veterinary Ophthalmology 6 (1), pp 73-76.



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