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Multicentric intravascular lymphoma in the nervous system of a dog (case report)
Multicentric lymphomas belong to the most common diagnosed neoplasias in the dog and tend to respond very well to chemotherapy. This is a very unusual case: First, the lymphoma was intravascular, affecting central and peripheral nervous system and leading to neurological signs. Second, it progressed despite chemotherapy was performed. A very interesting case!

A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months’ duration and recurrent seizures during the preceding 2 weeks.

Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified.

Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease.

A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma.

The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine.

Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems.

This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.





Source: William W. Bush, Juliene L. Throop, Patricia M. McManus, Amy S. Kapatkin, Charles H. Vite, Tom J. Van Winkle (2003): Intravascular Lymphoma Involving the Central and Peripheral Nervous Systems in a Dog. In: Journal of the American Animal Hospital Association 39:90-96 (2003)



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SMALL ANIMAL PRACTICE

Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Thus, the objective of this study was to investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.

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