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Multicentric intravascular lymphoma in the nervous system of a dog (case report)
Multicentric lymphomas belong to the most common diagnosed neoplasias in the dog and tend to respond very well to chemotherapy. This is a very unusual case: First, the lymphoma was intravascular, affecting central and peripheral nervous system and leading to neurological signs. Second, it progressed despite chemotherapy was performed. A very interesting case!

A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months’ duration and recurrent seizures during the preceding 2 weeks.

Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified.

Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease.

A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma.

The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine.

Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems.

This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.





Source: William W. Bush, Juliene L. Throop, Patricia M. McManus, Amy S. Kapatkin, Charles H. Vite, Tom J. Van Winkle (2003): Intravascular Lymphoma Involving the Central and Peripheral Nervous Systems in a Dog. In: Journal of the American Animal Hospital Association 39:90-96 (2003)



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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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