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Oral doxycycline, niacinamide and prednisolone in bilateral nodular granulomatous conjunctivitis
The combination of doxycycline and niacinamide is commonly used to treat certain autoimmune or immune mediated skin problems in dogs. But obviously it can also be very helpful to treat ocular diseases like a nodular granulomatous conjunctivitis of the third eyelid. A very interesting case report from Australia.

A 5-year-old, female neutered, Australian Kelpie presented with a 2-month history of dramatic bilateral erythematous thickening of the third eyelids.

Ophthalmic examination demonstrated raised, pink to red, irregular thickening of the entire palpebral surface of both third eyelids. There were no other ocular abnormalities.

A surgical biopsy was taken from each third eyelid.

Histopathologic examination revealed sheets of macrophages, plasma cells, lymphocytes, and occasional fibroblasts and neutrophils infiltrating the third eyelid stroma.

A diagnosis of chronic granulomatous conjunctivitis was made.

Grossly and histopathologically this case closely resembles previously described cases of nodular granulomatous conjunctivitis involving the third eyelids of Collie dogs.

This report describes an unusual case of nodular granulomatous conjunctivitis isolated to the third eyelids in an Australian Kelpie.

Resolution of the condition was achieved with a combination of oral doxycycline, niacinamide and prednisolone.



Source: Hurn, Simon, Mc Cowan, Christina & Turner, Andrew (2005): Oral doxycycline, niacinamide and prednisolone used to treat bilateral nodular granulomatous conjunctivitis of the third eyelid in an Australian Kelpie dog. In: Veterinary Ophthalmology 8 (5), 349-352.











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