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Efficacy of terbinafine and ketoconazole against Malassezia in dogs
Malassezia dermatitis and otitis is commonly diagnosed in dogs, especially in certain breeds like bassets. Oral ketoconazole is a well established and effective therapeutic option. In this study performed on 21 beagles, the efficacies of terbinafine and ketoconazole against malassezia yeasts were compared.

Twenty-one Basset Hounds were randomised in three groups of seven according to Malassezia populations. Dogs in the first group were treated by oral administration of ketoconazole (Ketofungol® 200 mg, Janssen-Cilag) at 10 mg kg1, every 24 h with food, for 3 weeks. Dogs in the second group were treated by oral administration of terbinafine (Lamisil® 250 mg, Novartis) at 30 mg kg1, every 24 h with food, for 3 weeks. The seven remaining dogs were used as controls. Malassezia population sizes were assessed by use of contact plates on four cutaneous sites at days 7, 14 and 21. Both ketoconazole and terbinafine were effective in reducing the baseline levels of Malassezia organisms with no significant difference between the two drugs. In further studies, oral terbinafine should be evaluated for the management of canine cases of Malassezia dermatitis.


Source: Guillot, J., Bensignor, E., Jankowski, F., Seewald, W., Chermette, R., Steffan, J.(2003): Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds. In: Veterinary Dermatology 14 (3), pp 153-157





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