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Therapy-refractory pododermatitis - a novel disease?
Chronic pododermatitis with no detectable underlying disease - the nightmare of every dermatologist. Maybe we are dealing with a new disease which should be called immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis and is accompanied by changes of serum immunoglobulines. A very fascinating and useful study!

Clinical, immunological and histopathological findings in 20 adult dogs of varying breeds with chronic (¡Ý 6 months) inflammation confined to the pedal skin were compared over a 2-year period with those of a group of age-matched controls (n = 20).

All affected dogs were pruritic but systemically well.

Lesions were present on all four feet in 18/20 cases.

Affected feet were characteristically erythematous, swollen, painful and alopecic.
Sinus tracts were evident in 4/20 dogs.

Despite a methodical series of diagnostic tests, no underlying cause was identified.

None of the dogs responded to antimicrobial therapy administered for 8 weeks, none had evidence of ectoparasitism and none satisfied the criteria for atopic dermatitis.
There was no response to a dietary trial using a novel protein source.

The condition was characterized histopathologically by epidermal hyperplasia, hyperkeratosis, spongiosis, dermal oedema and perivascular aggregates of lymphocytes and plasma cells.

Clinical signs did not correlate with histopathological findings.

Affected dogs had significantly elevated serum IgG and IgM concentrations. The results of lymphocyte proliferation assays and phenotypic studies to determine the relative percentage of CD3+, CD4+, CD8+ and CD21+ lymphocyte subsets, and the ratio of CD4+/CD8+ cells were not significantly different between groups.

No age, sex or seasonal predilections were noted.

All dogs subsequently responded to immunosuppressive doses of prednisolone or cyclosporin.

The term immunomodulatory-responsive lymphocytic¨Cplasmacytic pododermatitis is proposed to denote what may be a previously unrecognized condition in some dogs with pododermatitis of undetermined aetiology.


Source: BREATHNACH, RORY M., BAKER, KENNETH P., QUINN, PATRICK J, MCGEADY, THOMAS A., AHERNE, CAROL M. & JONES, BOYD R. (2005): Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. In: Veterinary Dermatology 16 (6), 364-372.






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SMALL ANIMAL PRACTICE

The expression of Vitamin D receptors in dogs
There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog.
The objectives of this recently online published study were to define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine.

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