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Medetomidine-propofol-combination in dogs
It has become a popular combination in the last years: medetomidine plus propofol. Various protocols are described. Here is one which has been shown as a safe combination of anesthetic drugs together with atropine...

Hemodynamic and analgesic effects of medetomidine (30 micrograms/kg of body weight, IM), atropine (0.044 mg/kg, IM), and propofol (2 mg/kg, IV, as a bolus, and 165 micrograms/kg/min, IV, for 60 minutes, as an infusion) were evaluated in 6 healthy adult Beagles.

Catheters were placed while the dogs were anesthetized with isoflurane in oxygen.

Administration of isoflurane was then discontinued, and dogs were allowed to breath oxygen until end-tidal isoflurane concentration was < or = 0.5%.

At this time, baseline measurements were recorded and medetomidine and atropine were administered. Ten minutes later, the bolus of propofol was given and the infusion was begun.

Analgesia was evaluated with a tail clamp test and by use of a direct-current nerve stimulator.

Sinoatrial and atrioventricular blockade developed in all 6 dogs within 2 minutes of administration of medetomidine and atropine, but disappeared within 10 minutes.

Apnea did not develop after administration of propofol.

Analgesia was strong and consistent throughout the entire 60-minute period of propofol infusion. Medetomidine significantly (P < 0.05) increased systemic vascular resistance and decreased cardiac output, compared with baseline values.

Propofol infusion appeared to alleviate medetomidine-induced vasoconstriction.

Recovery was smooth and uncomplicated.

All dogs were able to walk normally at a mean time (+/- SEM) of 88.2 +/- 20.6 minutes after termination of propofol infusion.

It was concluded that medetomidine, atropine, and propofol, as given in the present study, is a safe combination of anesthetic drugs for use in healthy Beagles.



Source: Thurmon JC, Ko JC, Benson GJ, Tranquilli WJ, Olson WA (1994): Hemodynamic and analgesic effects of propofol infusion in medetomidine-premedicated dogs. In: Am J Vet Res. 1994 Mar;55(3):363-7.



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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breedā€specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breedā€specific RIs, where appropriate.

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