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Immunolocalization of aquaporin-5 expression in sweat gland cells of horses
Horses sweat for thermoregulation, as everybody knows. But where is the aquaporin 5 localized in the sweat gland, and which differences exist between `normal` and anhydrotic horses? An interesting recently published study...

Western blot analysis showed that sweat gland cells from freely sweating horses expressed the water channel aquaporin-5 (AQP-5).

Immunohistochemistry revealed a strong AQP-5-like activity reaction at the apical membrane of the glandular secretory cells, which was absent from the surrounding myoepithelium and all other skin structures.

In anhidrotic horses, AQP-5 was also found at the apical membrane of the luminal sweat gland cells, but the level of expression reduced with the length of time that the animal had displayed anhidrosis.

The level of AQP-5 expression was substantially reduced in animals with long-term anhidrosis, hence implicating water channel impairment as a possible factor in the development of this disorder.



Source: BOVELL, DOUGLAS L., LINDSAY, SUSAN L., CORBETT, ALISTAIR D. & STEEL, CATHERINE (2006)
Immunolocalization of aquaporin-5 expression in sweat gland cells from normal and anhidrotic horses. In: Veterinary Dermatology 17 (1), 17-23.





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EQUINE

Two regimens of lidocaine infusion in horses undergoing laparotomy for colicmembers
Various lidocaine protocols are described for horses undergoing Colic surgery. This interesting prospective, randomized clinical study compares the effects of administering or not administering a loading intravenous (IV) bolus of lidocaine prior to its constant rate infusion (CRI). Effects investigated during isoflurane anaesthesia were end-tidal isoflurane concentration (Fe′ISO), cardiovascular function, anaesthetic stability and the quality of recovery.
Thirty-six client-owned horses were enrolled.

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