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Immunolocalization of aquaporin-5 expression in sweat gland cells of horses
Horses sweat for thermoregulation, as everybody knows. But where is the aquaporin 5 localized in the sweat gland, and which differences exist between `normal` and anhydrotic horses? An interesting recently published study...

Western blot analysis showed that sweat gland cells from freely sweating horses expressed the water channel aquaporin-5 (AQP-5).

Immunohistochemistry revealed a strong AQP-5-like activity reaction at the apical membrane of the glandular secretory cells, which was absent from the surrounding myoepithelium and all other skin structures.

In anhidrotic horses, AQP-5 was also found at the apical membrane of the luminal sweat gland cells, but the level of expression reduced with the length of time that the animal had displayed anhidrosis.

The level of AQP-5 expression was substantially reduced in animals with long-term anhidrosis, hence implicating water channel impairment as a possible factor in the development of this disorder.



Source: BOVELL, DOUGLAS L., LINDSAY, SUSAN L., CORBETT, ALISTAIR D. & STEEL, CATHERINE (2006)
Immunolocalization of aquaporin-5 expression in sweat gland cells from normal and anhidrotic horses. In: Veterinary Dermatology 17 (1), 17-23.





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EQUINE

Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
Septic keratitis is occasionally seen in various species. The aim of this study was to evaluate the most common bacterial pathogens associated with septic keratitis in veterinary patients from Switzerland. The second objective was to analyze antibiotic susceptibility test results of the identified bacterial pathogens. The third objective was to evaluate potential breed predispositions to septic keratitis. A very interesting study with results not only important for Switzerland!

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