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Immunolocalization of aquaporin-5 expression in sweat gland cells of horses
Horses sweat for thermoregulation, as everybody knows. But where is the aquaporin 5 localized in the sweat gland, and which differences exist between `normal` and anhydrotic horses? An interesting recently published study...

Western blot analysis showed that sweat gland cells from freely sweating horses expressed the water channel aquaporin-5 (AQP-5).

Immunohistochemistry revealed a strong AQP-5-like activity reaction at the apical membrane of the glandular secretory cells, which was absent from the surrounding myoepithelium and all other skin structures.

In anhidrotic horses, AQP-5 was also found at the apical membrane of the luminal sweat gland cells, but the level of expression reduced with the length of time that the animal had displayed anhidrosis.

The level of AQP-5 expression was substantially reduced in animals with long-term anhidrosis, hence implicating water channel impairment as a possible factor in the development of this disorder.



Source: BOVELL, DOUGLAS L., LINDSAY, SUSAN L., CORBETT, ALISTAIR D. & STEEL, CATHERINE (2006)
Immunolocalization of aquaporin-5 expression in sweat gland cells from normal and anhidrotic horses. In: Veterinary Dermatology 17 (1), 17-23.





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An 11‐year‐old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, and liver biopsy histopathologic findings were supportive of Theiler`s disease. Polymerase chain reaction (PCR) testing results of serum and liver tissue were positive for nonprimate (equine) hepacivirus (NPHV) and a novel equine parvovirus‐hepatitis virus (EqPV‐H). A serious and finally fatal problem, caused by contaminated vaccine.

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