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Osteolytic osteomyelitis in a dog with visceral leishmaniasis
Leishmaniasis can mimic nearly every cutaneous or extracutaneous disease, as everybody knows. Here is a very fascinating case report from Brazil where the affected dog showed weight loss and lameness of a hindleg - not very specific for any disease...

A dog was examined with a history of weight loss and lameness of the left hind limb.

A painful response to examination of the left hip joint, and lymphadenopathy were noted.

Amastigote forms of Leishmania sp. were observed by cytology in samples from the popliteus lymph node, and anti-Leishmania sp. antibodies at a titer of 1:640 were detected in serum by indirect immunofluorescence.

Radiological changes included osteolysis and a periosteal proliferative reaction in the left femoral greater trochanter.

These changes were histologically characterized as an osteolytic granulomatous osteomyelitis associated with amastigotes within macrophages.

Non-decalcified fragments of the periosteum were processed for immunohistochemistry, observed with prominent immunolabelling of amastigotes of Leishmania sp. within macrophages.

The diagnosis was further confirmed by positive PCR for Leishmania sp., belonging to the Leishmania donovani complex.



Source: de Souza AI, Juliano RS, Gomes TS, de Araujo Diniz S, Borges AM, Tafuri WL, Santos RL. (2005):Osteolytic osteomyelitis associated with visceral leishmaniasis in a dog. In: Vet Parasitol. 2005 Apr 20;129(1-2):51-4.



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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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