Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Equine /     
 
Lymphocyte alterations in horses with COPD
Chronic obstructive pulmonary disease (COPD) is a common problem in horses all over the world. Many causes have already be identified, and also a number of laboratory findings in these patients have been described. This is a very interesting study evaluating the alterations in lymphocyte subsets as well in the peripheral blood as in the bronchoalveolar lavage fluid (BALF) and in pulmonary biopsy frozen tissue sections.

The lymphocate subsets were investigated by using monoclonal antibodies to identify CD3+, CD4+, CD8+, and surface immunoglobulin positive (sIg+) lymphocytes.

COPD-affected horses (n = 5) and normal controls (n = 5) were sampled prestabling and 14 days poststabling, at which time the COPD-affected horses wee exhibiting clinical signs of COPD. The peripheral blood absolute CD4+ lymphocyte count was significantly elevated in the COPD-affected horses pre- and poststabling.

The CD4:CD8 ratio in peripheral blood of COPD-affect horses was unaffected by stabling, but the same ratio in the control horses was significantly decreased.

These findings support a hypothesis of deficient regulation of a systemic immune response to indoor air in the COPD-affected horses.

A large population of leukocytes in pulmonary biopsy immunohistochemical sections from both groups of horses appeared to be CD3+ CD4- CD8-, an uncommon phenotype in both the peripheral blood and BALF.




Source: J. L. Watson, J. L. Stott, M. T. Blanchard, J. P. Lavoie, W. D. Wilson, L. J. Gershwin and D. W. Wilson (1997): Phenotypic characterization of lymphocyte subpopulations in horses affected with chronic obstructive pulmonary disease and in normal controls. In: Veterinary Pathology, Vol 34, Issue 2 108-116.




Tell a friend   |   Print version   |   Send this article

EQUINE

Theiler´s disease in a Trakehner caused by contaminated tetanus vaccinemembers
An 11‐year‐old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, and liver biopsy histopathologic findings were supportive of Theiler`s disease. Polymerase chain reaction (PCR) testing results of serum and liver tissue were positive for nonprimate (equine) hepacivirus (NPHV) and a novel equine parvovirus‐hepatitis virus (EqPV‐H). A serious and finally fatal problem, caused by contaminated vaccine.

  • Limbal squamous cell carcinoma in a Rocky Mountain Horse and geneticsmembers
  • Subconjunctival bupivacaine, lidocaine, and mepivacaine and the corneal sensitivity in horsesmembers
  • Clodronate in horses with lamenessmembers
  • Valacyclovir in horses with equine multinodular pulmonary fibrosismembers
  • Radiculopathy associated with forelimb lameness in horsesmembers
  • Biological variations of routine blood parameters in horsesmembers
  • Prognosis for horses with deep digital flexor tendon injury after penetrating woundmembers
  • Possible maternal effect for the pace trait of horsesmembers
  • Flecainide on induced atrial fibrillation in horsesmembers
  • Sonographic technique to identify manica flexoria tears in horsesmembers
  • Novel prototype dynamic laryngoplasty system on arytenoid abductionmembers
  • Lipid peroxidation biomarkers in equine neuroaxonal dystrophymembers


  • [ Home ] [ About ] [ Contact / Request ] [ Privacy Policy ]

    Copyright © 2001-2018 VetContact GmbH
    All rights reserved