Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Ciclosporin in suspected granulomatous meningoencephalomyelitis in three dogs
Since ciclosporin has been introduced in veterinary medicine it is used in a variety of diseases which have been treated with corticosteroids before. This brandnew case report in 3 dogs suffering from the idiopathic disease granulomatous meningoencephalomyelitis is very interesting. One of the results: ciclosporin is effective but takes longer than corticosteroids before clinical improvement can be seen - same as in canine atopic dermatitis...

Granulomatous meningoencephalomyelitis is an idiopathic disease of the central nervous system of presumed dysimmune origin.

This disorder is characterised histologically by an angiocentric inflammatory reaction involving the brain, the spinal cord, and/or the leptomeninges. To date, the standard treatment for granulomatous meningoencephalomyelitis consists of immunosuppressive dosages of glucocorticoids.

Ciclosporin A, a potent immunosuppressive agent that blocks the transcription of cytokine genes in activated T cells, has been proposed as a therapeutic alternative.

In the present study of three dogs with suspected granulomatous meningoencephalomyelitis, microemulsified ciclosporin, at a dose of 10 mg/kg once daily for at least six weeks, then reducing to 5 mg/kg daily, was administered after a variable period of glucocorticoid treatment, and resulted in a complete resolution of clinical signs.

Satisfactory improvement of clinical signs after ciclosporin administration took more time than after glucocorticoid administration.

Six weeks after the beginning of ciclosporin treatment, clinical results were similar to those obtained with prednisolone.

Adverse effects were minimal with ciclosporin, with only intermittent vomiting.



Source: Gnirs, K. (2006): Ciclosporin treatment of suspected granulomatous meningoencephalomyelitis in three dogs. In: Journal of Small Animal Practice 47 (4), 201-206.




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Brachycephalic airway syndrome - differences between pugs and French bulldogs
Does the brachycephalic airway syndrome mean the same in all brachycephalic breeds or are there breed-specific differences? A fascinating question was raised. This retrospective study including 72 dogs aimed to compare clinical features of brachycephalic airway syndrome and long-term surgical outcomes between pugs and French bulldogs and evaluate the influence of laryngeal collapse.

  • Prognostic factors in cats with HCMmembers
  • Ureteral Papilla Implantation in Cats Undergoing Renal Transplantationmembers
  • Storage lesion in canine packed erythrocytesmembers
  • Drug-induced infiltrative lung disease with cytarabine and prednisonemembers
  • Laparoscopic-assisted Gastropexy and the Gastrointestinal Transit Time in Dogsmembers
  • Transpalpebral ultrasonographic evaluation and measurement of the optic nerve members
  • Squamous cell carcinoma mimicking orbital myofibroblastic sarcomamembers
  • Unusual case of feline acute corneal hydropsmembers
  • Shock index in identifying acute blood loss in healthy dogsmembers
  • Correlation of direct in-house cerebrospinal fluid cytology with commercial pathology results members
  • 3 Serological Tests for Early Detection Of Leptospira-specific Antibodies members
  • Patient-specific facemask to facilitate brain biopsymembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved