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Correlation of CT-MRI and histopathology in dogs with brain neoplasms
Brain tumours in dogs can be very hard to diagnose, and new diagnostic techniques like CT and MRI are thought to be superior to x-rays. This very interesting study evaluates the correlation of the diagnostic results with the histopathology. The correlation was better than suspected, especially with contrast enhancement.

Ten dogs with primary (n = 8) and metastatic (n = 2) brain tumours were studied in an attempt to evaluate the diagnostic sensitivity of computed tomography (CT) or magnetic resonance imaging (MRI).

Of the clinical signs noticed, seizures (seven of 10), behavioural abnormalities and cognition dysfunction (seven of 10), compulsive walking and circling (six of 10), sensorimotor (five of 10) and neuro-opthalmological (two of 10) dysfunction were the most common.

In all 10 animals that finally died of the disease or were killed, the histopathological diagnosis that followed necropsy was taken as a golden standard in the CT or MRI prediction of the histological type of brain neoplasms.

In every instance, tumour detection, morphology and histological differentiation were possible with the aid of either CT (seven of 10) or MRI (three of 10) imaging especially after contrast enhancement.

Only one CT-evaluated dog, diagnosed as meningioma, was found to be astrocytoma on histopathology. Interestingly, a rare case of cerebellar medulloblastoma was correctly identified in MRI scans.


Source: Polizopoulou ZS, Koutinas AF, Souftas VD, Kaldrymidou E, Kazakos G, Papadopoulos G. (2003): Diagnostic correlation of CT-MRI and histopathology in 10 dogs with brain neoplasms. In: J Vet Med A Physiol Pathol Clin Med. 2004 Jun;51(5):226-31


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SMALL ANIMAL PRACTICE

Novel intratumoral therapy in canine transmissible venereal tumour
Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the immune status of the host. The aim was to investigate recombinant human interferon alpha‐2a (rhIFNα‐2a) and vincristine for treatment of CTVT.

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