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Lidocaine 5% patch in dogs
Patches with analgetics, hormones, nicotine etc. are very popular in human medicine. Lidocaine is increasingly used in transdermal drug delivery systems for different pain conditions in human medicine whereby several pharmacokinetic studies have demonstrated minimal systemic absorption in men. Can it also be used for dogs? An important question and an interesting study from Belgium.



In the present study, the pharmacokinetics of a lidocaine patch 5% was studied in six dogs.

In the first experiment, one single lidocaine patch was applied for 12 h to the lateral side of the thorax after removing the hair either by clipping or by the application of a depilatory agent, according to a two-way crossover design.

No potential adverse effects induced by the patches were observed in either group.

In dogs with clipped hair, a mean peak plasma lidocaine concentration of 62.94 ng/ml was obtained after 10.67 h. In the depilatory group, a mean peak plasma concentration of 103.55 ng/ml was reached after 9.27 h. Significant differences in the AUC0 , Cmax, ka and T1/2a were noticed between the two groups.
No significant differences were found for the elimination parameters and for Tmax.

In the second experiment, the patches were applied for 60 h to the clipped skin in order to study the absorption kinetics after a prolonged application period.

There, the mean peak lidocaine plasma concentration was 45.18 ng/ml achieved after 24 h and a final concentration of 29.37 ng/ml was obtained at 60 h.

In conclusion, all dogs tolerated the transdermal lidocaine patch well.

The results of this study suggest that there is an overall minimal absorption from the lidocaine patch. However, the application of a depilatory agent leads to a more rapid and increased absorption of lidocaine.



Source: Weiland, L., Croubels, S., Baert, K., Polis, I., De Backer, P. & Gasthuys, F. (2006): Pharmacokinetics of a Lidocaine Patch 5% in Dogs. In: Journal of Veterinary Medicine Series A 53 (1), 34-39.



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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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