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Successful management of CNS dysfunction due to Rocky Mountain spotted fever
Rocky Mountain spotted fever (RMSF), caused by Rickettsia rickettsii, is a well-known problem in certain areas of the USA. Normally, the mortality rate increases if CNS signs occur. But as these case reports show, it is worth to treat these dogs.

Five dogs from the northeastern United States were presented with clinical signs of neurological disease associated with Rocky Mountain spotted fever (RMSF) infection.

Four of the five dogs had vestibular system dysfunction.
Other neurological signs included paresis, tremors, and changes in mentation.

All of the dogs had an elevated indirect fluorescent antibody titer or a positive semiquantitative enzyme screening immunoassay titer for Rickettsia rickettsii at the time of presentation.

Although a higher mortality rate has been reported for dogs with neurological symptoms and RMSF infection, all of the dogs in this study improved with appropriate medical therapy and supportive care.

Source: Jessica S. Mikszewski, Charles H. Vite (2005): Central Nervous System Dysfunction Associated With Rocky Mountain Spotted Fever Infection in Five Dogs. In: Journal of the American Animal Hospital Association 41:259-266 (2005)



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SMALL ANIMAL PRACTICE

Toceranib phosphate (Palladia®) in canine gastrointestinal stromal tumorsmembers
Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. High‐risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. This recently online published study reviews cases of toceranib phosphate use in dogs with GISTs and provides initial assessment of possible biological activity. A secondary aim was to evaluate patient and tumor characteristics for possible prognostic value.

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