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Experimental Plague in Cats - histopathologic findings
Yersinia pestis is the organism causing bubonic plague in humans. Seven cats were experimentally infected with these bacilli and their tissues were examined to see if also this species developes bubonic plague lesions and how they can be characterized histopathologically. Very interesting!

Formalin-fixed paraffin-embedded archival tissues of seven adult cats of both sexes that died after being experimentally infected with Yersinia pestis were examined light microscopically to characterize the lesions.

The cats were exposed in two groups using two routes of infection: ingestion of Y. pestis-infected rodent or a subcutaneous injection of Y. pestis to simulate a flea bite.

Immunohistochemistry was performed on tissues from all organ systems from a representative cat from each group to determine the distribution of Y. pestis bacilli during infection.

In all seven cats, bubonic plague lesions were seen.

The lesions of pneumonic plague were present in two cats.

Septicemic plague was confirmed in all seven cats by bacteriologic culture. A

ggregations of bacteria were seen in lymphoid tissue in all cats and in lung tissues from the two cats with pneumonic plague.

The most consistent histologic finding was necrosuppurative inflammation in the lymph nodes. Invariably, Y. pestis bacteria were present in large numbers at affected sites.

Orally infected cats had more numerous lesions in the lymph nodes of the head and neck regions. These experimentally induced cases of feline plague document that cats are unique among carnivores in exhibiting bubonic, pneumonic, and septicemic plague following exposure to Y. pestis.

The lesions of the orally infected cats were consistent with those previously described for naturally occurring Y. pestis infections in cats and corroborate the contention that cats most commonly contract plague by eating Y. pestis-infected rodents and not via flea bite.

The histopathology of Y. pestis disease in these cats is comparable to that described for human plague.

Source: R. P. Watson, T. W. Blanchard, M. G. Mense and P. W. Gasper (2001): Histopathology of Experimental Plague in Cats. In: Vet Pathol 38:165-172 (2001)





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