|The relationship between the presence of PV antigens and the clinical and histological features of 26 cases of feline dermatoses (clinically described as pigmented plaques and with histological diagnosis of FVP and/or BISC) was therefore determined.
The cases were classified into one of the three following groups: FVP, FVP + BISC or BISC. Immunohistological detection of papillomavirus group-specific antigen was performed using a polyclonal rabbit antibovine papillomavirus antiserum.
Of the seven cases in the FVP group, six were deemed positive by immunohistology as were all 10 cats in the FVP + BISC group.
On the other hand, only one of the nine BISC cats was positive.
The presence of both FVP and BISC lesions in some cats and the high detection rate of PV antigens in the FVP and FVP + BISC groups suggest that both conditions might have the same viral cause and that some BISC may evolve from FVP.
The low rate of viral antigen detection in the BISC group indicates another cause or a loss of viral replication during the cancerogenesis.
Source: Wilhelm, Sylvia, Degorce-Rubiales, Frederique, Godson, Dale & Favrot, Claude (2006). Clinical, histological and immunohistochemical study of feline viral plaques and bowenoid in situ carcinomas. In: Veterinary Dermatology 17 (6), 424-431.
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