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Intestinal T-cell lymphoma in dogs
Among the intestinal tumors of hematopoietic cell origin, lymphoma is the most common in the dog. This eleven cases including study gives interesting new insights in this disease - for example that these tumors always affected the small intestine, attracted eosinophils and resembled mast cell tumors.

Herein, we characterized the clinical and pathologic features of 11 dogs (average age, 10.6 ± 2.5 years) with T-cell lymphoma of the intestinal tract with eosinophil infiltrates.

No sex predominance was apparent. All had localized tumor masses in the small intestine. Grossly, the intestinal wall was thickened, and the lumen of the affected intestine was usually narrowed.

Microscopically, we observed transmural diffuse invasion of round to pleomorphic tumor cells. Tumor cells showed varying morphology, from scanty to abundant cytoplasm, and round to ovoid nuclei with scattered to dense chromatin.

In seven of the dogs, tumor cells had infiltrated into the epithelium.

All showed infiltration of eosinophils and all 11 tumors had a T-cell phenotype (CD3+, CD79–). Only one tumor stained positive for the mast cell marker c-kit and none was positive for mast cell tryptase.

We did not observe ultrastructurally apparent granules in any of the tumor cells. These results suggest that, in dogs, T-cell lymphomas of intestinal origin resemble mast cell tumors of intestinal origin with respect to cell structure and eosinophil infiltration.

Therefore, in the absence of epitheliotropism, it is difficult to confirm the differential diagnosis without immunostaining for mast cell and lymphocyte markers, including mast cell tryptase, c-kit, CD3, and CD79.



Source: K. Ozaki, T. Yamagami, K. Nomura and I. Narama (2006): T-Cell Lymphoma with Eosinophilic Infiltration Involving the Intestinal Tract in 11 Dogs. In: Vet Pathol 43:339-344 (2006)




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SMALL ANIMAL PRACTICE

Radioactive iodine uptake in hyperthyroid cats after rh-TSHmembers
Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Thus, the objective of this study was to investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.

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