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Surgical, systemic and topical therapy of nasal aspergillosis
None of these therapies is really new in canine nasal aspergillosis, and none of them as monotherapy has become really convincing in the last years. Is the combination of all three approaches the therapeutic nonplusultra?

The objective of this study was to evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis.

METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure.

In the main study group, the bone flap was discarded.

Nasal passages were debrided and irrigated with enilconazole solution for one hour.

Oral itraconazole was administered to four dogs for one month postoperatively.

Follow-up rhinoscopy was performed in all dogs.

RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap.
The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery.
At follow-up rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic.
Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis.

CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis.



Source: Claeys S, Lefebvre JB, Schuller S, Hamaide A, Clercx C. (2006): Surgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole. In: J Small Anim Pract. 2006 Jun;47(6):320-4.



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SMALL ANIMAL PRACTICE

The expression of Vitamin D receptors in dogs
There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog.
The objectives of this recently online published study were to define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine.

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