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Coma and apnea in a dog with hydroxyzine toxicosis (case report)
Hydroxyzine is a commonly used antihistamine in canine atopic dermatitis. The most common side affects are mild sedation and gastrointestinal problems. This case report describes a severe, comatous adverse reaction in one dog.


The most common adverse effect of hydroxyzine reported after therapeutic dosing is mild sedation; severe reactions resulting in coma have occasionally been reported in children.

We present a case of large po hydroxyzine exposure causing in coma and apnea in a dog.

Exposure was confirmed with gas chromatography/mass spectrometry analysis of urine. Extensive therapeutic measures to enhance drug elimination and assist ventilation were required for IId.

The positive outcome justifies critical care of similarly exposed animals. Veterinarians should be aware of the potential for coma and apnea secondary to hydroxyzine exposure.

Source: JH Tegzes, SD Smarick, B Puschner (2002): Coma and apnea in a dog with hydroxyzine toxicosis. In: Veterinary and Human Toxicology, 2002, Vol 44, Iss 1, pp 24-26






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