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Imidacloprid/moxidectin combination against naturally acquired canine scabies
Scabies (sarcoptic mange) is a common and highly pruritic disease in dogs which often is misdiagnosed as an allergy. Some therapies are very efficious but not licensed in dogs. Is the licensed and very comfortable therapy with an imidacloprid plus moxidectin spot-on formulation both licensed and efficious?

The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v) / moxidectin (2.5% w/v) combination (Advocate® Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs.

Thirty naturally infested dogs, of which one was later withdrawn because of distemper, were allocated to two equal groups and individually housed.

The dogs in each group were treated twice, four weeks apart, with either the combination product (0.1 mL/kg body weight) or with selamectin (0.05 mL/kg body weight) administered topically. Skin scrapings were made every 14 days over a period of 50 to 64 days after the first treatment to quantify mite numbers.

Clinical signs and the extent of sarcoptic lesions were assessed on each dog when skin scrapings were made.

Efficacy was based on the presence or absence of mites, supported by clinical signs associated with canine sarcoptic mange. From Day 22 and onwards no Sarcoptes mites were found in the skin scrapings of any of the treated dogs.

Treatment with the imidacloprid/moxidectin formulation or with selamectin was highly effective against Sarcoptes scabiei and resulted in an almost complete resolution of clinical signs within 50 to 64 days after the initial treatment.


Source: LJ FOURIE, J. HEINE, IG HORAK (2006): The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs. In: Australian Veterinary Journal 84 (1-2), 17–21.


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SMALL ANIMAL PRACTICE

Punctate retinal hemorrhage in dogsmembers
Punctate retinal hemorrhage is occasionally seen in dogs and sometimes associated with ocular or systemic disease. This recently online published study describes clinical aspects of dogs with punctate retinal hemorrhage (PRH) on 83 dogs (119 eyes) with PRH. One of the interesting findings: 60% of the affected dogs suffered from a systemic disease!

  • Classification system for cleft lip and palate in dogsmembers
  • Atypical hemolymphoid neoplasia causing aberrant CD3 expression in a dogmembers
  • Cell-Free DNA and DNase Activity in Dogs with IMHAmembers
  • Chronic Diarrhea in Dogs members
  • Safety of a benazepril and pimobendan combination tablet in healthy dogsmembers
  • Tear fluid collection with ophthalmic sponges in dogs and catsmembers
  • Metabolic and cardiac variables in dogs with obesitymembers
  • Vertebral heart size in chinchillas members
  • Receptor gene mutation causing postoperative hemorrhage in a Greater Swiss Mountain dogmembers
  • First description of severe type 3 VWD in a domestic cat members
  • Serum total cholesterol concentrations in dogs with osteosarcomamembers
  • Perfusion index to confirm the presence of sciatic nerve blockade in dogsmembers


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