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Imidacloprid/moxidectin combination against naturally acquired canine scabies
Scabies (sarcoptic mange) is a common and highly pruritic disease in dogs which often is misdiagnosed as an allergy. Some therapies are very efficious but not licensed in dogs. Is the licensed and very comfortable therapy with an imidacloprid plus moxidectin spot-on formulation both licensed and efficious?

The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v) / moxidectin (2.5% w/v) combination (Advocate® Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs.

Thirty naturally infested dogs, of which one was later withdrawn because of distemper, were allocated to two equal groups and individually housed.

The dogs in each group were treated twice, four weeks apart, with either the combination product (0.1 mL/kg body weight) or with selamectin (0.05 mL/kg body weight) administered topically. Skin scrapings were made every 14 days over a period of 50 to 64 days after the first treatment to quantify mite numbers.

Clinical signs and the extent of sarcoptic lesions were assessed on each dog when skin scrapings were made.

Efficacy was based on the presence or absence of mites, supported by clinical signs associated with canine sarcoptic mange. From Day 22 and onwards no Sarcoptes mites were found in the skin scrapings of any of the treated dogs.

Treatment with the imidacloprid/moxidectin formulation or with selamectin was highly effective against Sarcoptes scabiei and resulted in an almost complete resolution of clinical signs within 50 to 64 days after the initial treatment.


Source: LJ FOURIE, J. HEINE, IG HORAK (2006): The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs. In: Australian Veterinary Journal 84 (1-2), 17–21.


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SMALL ANIMAL PRACTICE

Concentrations of a marker of type I collagen metabolism in ragdolls with HCMmembers
HCM (hypertrophic cardiomyopathy) is a common and life-threatening disease in many cat breeds, and the diagnosis especially in an early stage is extremely difficult. Human carriers of hypertrophic cardiomyopathy associated sarcomeric mutations have abnormal collagen metabolism before overt left ventricular hypertrophy is detectable. This fascinating new study investigated whether differences in collagen biomarkers were present in blood samples of ragdoll cats positive for the MYBPC3:R820W mutation compared with negative controls.

  • Novel surgical technique for perineal hernia repairmembers
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  • Canine lacrimal and third eyelid glands - anatomy and morphometrymembers
  • Two bupivacaine delivery methods to control pain after enucleationmembers
  • Novel technique for severe maxillofacial fractures in dogs
  • Update to SARDS (Sudden acquired retinal degeneration syndrome)
  • Comparison between diagnostic imaging techniques of the elbow in medial coronoid disease
  • ELISA against circulating anti-asparaginase antibodies in dogs with lymphoid neoplasia
  • In vivo confocal microscopy for the diagnosis of canine fungal keratitis
  • Coagulation status in dogs with Angiostrongylus vasorum infectionmembers
  • CT pneumocolonography in healthy dogsmembers


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