Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Privacy Policy  
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Ephedrine and dopamine for the management of hypotension in dogs under isoflurane anesthesia
Even under isoflurane anesthesia, a very `modern` technique, hypotension can become a very serious problem in dogs. The cardiovascular responses of ephedrine and dopamine for the management of presurgical hypotension in 12 healthy anesthetized dogs were determined in this recently published study. One of the interesting findings: the first bolus of ephedrine works well, the second has nearly no effect...


The study was designed as a prospective, randomized, clinical trial. Twelve healthy client-owned dogs admitted for orthopedic surgery; six per group, were included.

Prior to surgery, 58 anesthetized dogs were monitored for hypotension [mean arterial pressure (MAP) <60 mmHg] that was not associated with bradycardia or excessive anesthetic depth. Ephedrine (0.2 mg kg1, IV) or dopamine (5 ìg kg1 minute1, IV) was randomly assigned for treatment in 12 hypotensive dogs.

Ten minutes after the first treatment (Tx1-10), ephedrine was repeated or the dopamine infusion rate was doubled.

Cardiovascular assessments taken at baseline, Tx1-10, and 10 minutes following treatment adjustment (Tx2-10) were compared for differences within and between treatments (p < 0.05).

Results: Ephedrine increased cardiac index (CI), stroke volume index (SVI), oxygen delivery index (DO2I), and decreased total peripheral resistance (TPR) by Tx1-10, while MAP increased transiently (<5 minutes). The second ephedrine bolus produced no further improvement.

Dopamine failed to produce significant changes at 5 ìg kg1 minute1, while 10 ìg kg1 minute1 increased MAP, CI, SVI significantly from baseline, and DO2I compared with Tx1-10. The improvement in CI, SVI, and DO2I was not significantly different between treatments at Tx2-10.

In anesthetized hypotensive dogs, ephedrine and dopamine improved cardiac output and oxygen delivery. However, the pressure-elevating effect of ephedrine is transient, while an infusion of dopamine at 10 ìg kg1 minute1 improved MAP significantly by additionally maintaining TPR.



Source: Hui C Chen, Melissa D Sinclair, Doris H Dyson (2007): Use of ephedrine and dopamine in dogs for the management of hypotension in routine clinical cases under isoflurane anesthesia*. In:
Veterinary Anaesthesia and Analgesia 34 (5), 301–311.



Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

  • Bioavailability of suppository acetaminophen in dogsmembers
  • Computed tomographic lymphography for lymph node staging in dogs with malignant tumors members
  • Characterization of ocular melanosis-affected canine melanocytesmembers
  • Nasopharyngeal sialoceles in brachycephalic dogsmembers
  • Enterococcus faecium SF68 on serum cobalamin and folate concentrationsmembers
  • Gastrointestinal eosinophilic sclerosing fibroplasia limited to the mesentery in a catmembers
  • Ion acid-base disturbances and associated mortality in dogsmembers
  • First description of ultrasonic bone curette in canine otic surgerymembers
  • Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
  • Oral extended release hydrocodone as analgesia after TPLOmembers
  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved