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Embryonic stem cells in companion animals
Reproductive technologies have made impressive advances since the 1950s owing to the development of new and innovative technologies. Most of these advances were driven largely by commercial opportunities and the potential improvement of farm livestock production and human health. What about embryonic stem cells in companion animals? A very interesting update!

Companion animals live long and healthy lives and the greatest expense for pet owners are services related to veterinary care and healthcare products.

The recent development of embryonic stem cell and nuclear transfer technology in primates and mice has enabled the production of individual specific embryonic stem cell lines in a number of species for potential cell-replacement therapy.

Stem cell technology is a fast-developing area in companion animals because many of the diseases and musculoskeletal injuries of cats, dogs and horses are similar to those in humans.

Nuclear transfer-derived stem cells may also be selected and directed into differentiation pathways leading to the production of specific cell types, tissues and, eventually, even organs for research and transplantaton.

Furthermore, investigations into the treatment of inherited or acquired pathologies have been performed mainly in mice.

However, mouse models do not always faithfully represent the human disease. Naturally occurring diseases in companion animals can be more ideal as disease models of human genetic and acquired diseases and could help to define the potential therapeutic efficiency and safety of stem cell therapies.

In the present review, we focus on the economic implications of companion animals in society, as well as recent biotechnological progress that has been made in horse, dog and cat embryonic stem cell derivation.

Source: Tecirlioglu RT, Trounson AO. (2007): Embryonic stem cells in companion animals (horses, dogs and cats): present status and future prospects. In: Reprod Fertil Dev. 2007;19(6):740-7.




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EQUINE

The farrier role in supporting horse owners to prevent laminitismembers
Emerging research highlights how, due to demographic changes in horse owner populations in Western societies, complex owner–horse relationships are leading to inappropriate horse care, including overnutrition, which in turn can lead to laminitis. Farriers, due to their regular visits, may be in a position to support owners in dealing with this problem. This study explored whether UK farriers have a role in working with horse owners to support horse welfare and prevent laminitis.

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  • Insulin and the structural integrity of equine digital lamellaemembers
  • Exercise-induced pulmonary haemorrhage in Thoroughbred racehorsesmembers
  • Specific bioactive collagen peptides (PETAGILE®) in horses with osteoarthritismembers
  • Epidural anaesthesia in horses with perineal and tail melanomasmembers
  • Unexpected cause of haematuria in an Egyptian Arabian stallionmembers
  • First description of hypersplenism in an old miniature ponymembers
  • Endocrinopathies associated with severe hypertriglyceridaemia in horses and poniesmembers
  • Clinical effect of corticosteroids in horses with asthmamembers
  • Severe complications of cheek tooth extraction in a ponymembers
  • Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
  • Traumatic coccygeal luxation and distal amputation of the tail of a horsemembers


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