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Embryonic stem cells in companion animals
Reproductive technologies have made impressive advances since the 1950s owing to the development of new and innovative technologies. Most of these advances were driven largely by commercial opportunities and the potential improvement of farm livestock production and human health. What about embryonic stem cells in companion animals? A very interesting update!

Companion animals live long and healthy lives and the greatest expense for pet owners are services related to veterinary care and healthcare products.

The recent development of embryonic stem cell and nuclear transfer technology in primates and mice has enabled the production of individual specific embryonic stem cell lines in a number of species for potential cell-replacement therapy.

Stem cell technology is a fast-developing area in companion animals because many of the diseases and musculoskeletal injuries of cats, dogs and horses are similar to those in humans.

Nuclear transfer-derived stem cells may also be selected and directed into differentiation pathways leading to the production of specific cell types, tissues and, eventually, even organs for research and transplantaton.

Furthermore, investigations into the treatment of inherited or acquired pathologies have been performed mainly in mice.

However, mouse models do not always faithfully represent the human disease. Naturally occurring diseases in companion animals can be more ideal as disease models of human genetic and acquired diseases and could help to define the potential therapeutic efficiency and safety of stem cell therapies.

In the present review, we focus on the economic implications of companion animals in society, as well as recent biotechnological progress that has been made in horse, dog and cat embryonic stem cell derivation.

Source: Tecirlioglu RT, Trounson AO. (2007): Embryonic stem cells in companion animals (horses, dogs and cats): present status and future prospects. In: Reprod Fertil Dev. 2007;19(6):740-7.




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EQUINE

Trema micrantha-associated neurotoxicosis
Trema micrantha is a tree widely distributed throughout the Americas. The tree produces highly palatable leaves that have been associated with natural poisoning in goats, sheep and horses, in which hepatic necrosis and hepatic encephalopathy have been observed.This retrospective case series describes malacia and haemorrhage in the central nervous system (CNS) due to T. micrantha consumption, with minimal to absent hepatic lesions.

  • Septic keratitis - associated bacteria and antibiotic susceptibilitymembers
  • Traumatic coccygeal luxation and distal amputation of the tail of a horsemembers
  • Head computed tomography in equine practicemembers
  • Standing intraoral extractions of cheek teeth in horsesmembers
  • Actinobacillus capsulatus peritonitis and chyloabdomen in a horsemembers
  • Adverse effect of an intrapleural tissue plasminogen activatormembers
  • Avulsion of the proximal digital annular ligament in five horsesmembers
  • Penile and preputial squamous cell carcinoma in the horse members
  • CT diagnosis of fatigue fracture of Mt 3 in young adult horsesmembers
  • Two regimens of lidocaine infusion in horses undergoing laparotomy for colicmembers
  • Biofilms of Candida spp. from the ocular conjunctiva of horses members
  • PARR clonality testing in a horse with a solitary retropharyngeal lymphomamembers


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