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Spontaneous osteosarcoma in a rabbit
Osteosarcomas are very rare in rabbits but common in dogs. This recently published case report from Japan describes a rabbit with an osteosarcoma at the same predilection site as a dog. Very informative!

A 6-year-old male cross-breed rabbit ( Oryctolagus cuniculus) was presented with lameness and severe swelling from the right shoulder to brachium.

On 16-detector helical computed tomography images of the amputated right forelimb after being fixed in formalin, evident proliferative and destructive lesions of bone were observed. On histologic examination, the tumor was composed of proliferating neoplastic cells that resembled histiocytes, with abundant osteoid production.

A large number of multinucleated giant cells were found throughout.

This case was diagnosed as osteosarcoma by clinical, radiographic, and histologic findings.

This is a rare case report of osteosarcoma in a rabbit consistent with canine predilection sites.


Source: H. Kondo, M. Ishikawa, H. Maeda, M. Onuma, M. Masuda, H. Shibuya, H. Koie and T. Sato (2007): Spontaneous Osteosarcoma in a Rabbit ( Oryctolagus cuniculus). In: Vet Pathol 44:691-694 (2007)




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SMALL ANIMAL PRACTICE

Proteasome inhibitors for canine and human osteosarcomamembers
Osteosarcoma, a common malignancy in large dog breeds, typically metastasises from long bones to lungs and is usually fatal within 1 to 2 years of diagnosis. Better therapies are needed for canine patients and their human counterparts, a third of whom die within 5 years of diagnosis. The authors compared the in vitro sensitivity of canine osteosarcoma cells derived from 4 tumours to the currently used chemotherapy drugs doxorubicin and carboplatin, and 4 new anti‐cancer drugs.

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