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Pseudothrombocytopenia (PTCP) secondary to EDTA in dogs
This phenomenon has already been describes in other species like horses and pigs and it should be considered in dogs with moderate thrombocytopenia and no clinical bleeding tendency. A very informative publication!

This type of pseudothrombocytopenia is not a pathological process by itself, but it can be clinically significant if diagnostics and medical treatments are initiated based on the reported thrombocytopenia.

Platelet clumping occurs with EDTA-dependent PTCP, resulting in inaccurate hematology analyzer platelet concentrations.

A nontraumatic venipuncture may be sufficient to obtain an accurate platelet count.

However, rare cases in the dog may require blood drawn into a different anticoagulant, such as sodium citrate, to help discriminate a true thrombocytopenia from PTCP.



Source: Tamara B. Wills, K. Jane Wardrop (2008):Pseudothrombocytopenia Secondary to the Effects of EDTA in a Dog. In: Journal of the American Animal Hospital Association 44:95-97 (2008)






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