Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
  Interferon  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Enalapril versus placebo in canine idiopathic glomerulonephritis
Enalapril is a well-known blocker of the ACE system in dogs and cats. Is it also effective in the therapy of naturally occurring, idiopathic glomerulonephritis in dogs?

Twenty-nine adult dogs were included in a blinded, multicenter, prospective clinical trial with membranous (n = 16) and membranoproliferative (n = 13).

Dogs were randomly assigned to receive either EN (0.5 mg/kg PO q12-24h; n = 16) or placebo (n = 14) for 6 months (1 dog was treated first with the placebo and then with EN). All dogs were treated with low-dose aspirin (0.5-5 mg/kg PO q12-24h) and fed a commercial diet. At baseline, serum creatinine (SrCr), systolic blood pressure (SBP), and glomerular histologic grade were not different between groups, but the urine protein/creatinine ratio (UP/C) was greater in the EN group compared with the placebo group (8.7 +/- 4.4 versus 4.7 +/- 2.3).
After 6 months of treatment, the change in UP/C from baseline was significantly different between groups (EN = -4.2 +/- 1.4 versus 1.9 +/- 0.9 in the placebo group). When data were adjusted for changes in SrCr (SrCr X UP/C) a similar significant reduction was noted ( 2.2 +/- 15.2 versus 8.4 +/- 10.1). The change in SBP after 6 months of treatment also was significantly different between groups (EN = -12.8 +/- 27.3 versus 5.9 +/- 21.5 mm Hg in the placebo group).

Response to treatment was categorized as improvement (assigned a value of 2), no progression (assigned a value of 1), and progression (assigned a value of 0).

Response was significantly better in the EN group (1.4 +/- 0.8) compared with the placebo group (0.3 +/- 0.5).
These results suggest that EN treatment is beneficial in dogs with naturally occurring idiopathic GN.

Source: Grauer GF,et al (2000): Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis. In: J Vet Intern Med 2000 Sep-Oct;14(5):526-33




Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Blood glucose in small animals with acute arterial thrombembolism
Acute limb paralysis because of arterial thromboembolism (ATE) occurs in cats and less commonly in dogs. ATE is diagnosed based on physical examination findings and, occasionally, advanced imaging. The objective of this prospective observational, clinical study was to evaluate if peripheral, affected limb venous glucose concentration is decreased in ATE, whereas its systemic concentration is within or above reference interval.

  • Troponin I and T as prognostic markers in feline HCM
  • Methicillin-resistant Staphylococcus (MRS) in dogs with naturally acquired bacterial keratitis
  • Chiari-Like Malformation and Syringomyelia in a non-Spaniel breedmembers
  • Maropitant versus acepromazine in hydromorphone premedicated dogsmembers
  • Angiogenesis and its markers in dogs with congenital portosystemic shunts members
  • Platelet Volume and Plateletcrit in dogs with immune mediated thrombocytopenia
  • Unilateral microphthalmia or anophthalmia in pythons
  • Cardiopulmonary effects of dexmedetomidine infusions in dogs undergoing isoflurane anesthesiamembers
  • Oxidative stress in acute versus chronic glaucomamembers
  • Dialysis disequilibrium-like clinical signs during postobstructive therapy of urethral obstructionmembers
  • Hetastarch 670/0.75 constant rate infusion and the platelet closure time in dogs members
  • Detection of venous air embolism via computed tomography members


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2013 VetContact GmbH
    All rights reserved