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Enalapril versus placebo in canine idiopathic glomerulonephritis
Enalapril is a well-known blocker of the ACE system in dogs and cats. Is it also effective in the therapy of naturally occurring, idiopathic glomerulonephritis in dogs?

Twenty-nine adult dogs were included in a blinded, multicenter, prospective clinical trial with membranous (n = 16) and membranoproliferative (n = 13).

Dogs were randomly assigned to receive either EN (0.5 mg/kg PO q12-24h; n = 16) or placebo (n = 14) for 6 months (1 dog was treated first with the placebo and then with EN). All dogs were treated with low-dose aspirin (0.5-5 mg/kg PO q12-24h) and fed a commercial diet. At baseline, serum creatinine (SrCr), systolic blood pressure (SBP), and glomerular histologic grade were not different between groups, but the urine protein/creatinine ratio (UP/C) was greater in the EN group compared with the placebo group (8.7 +/- 4.4 versus 4.7 +/- 2.3).
After 6 months of treatment, the change in UP/C from baseline was significantly different between groups (EN = -4.2 +/- 1.4 versus 1.9 +/- 0.9 in the placebo group). When data were adjusted for changes in SrCr (SrCr X UP/C) a similar significant reduction was noted ( 2.2 +/- 15.2 versus 8.4 +/- 10.1). The change in SBP after 6 months of treatment also was significantly different between groups (EN = -12.8 +/- 27.3 versus 5.9 +/- 21.5 mm Hg in the placebo group).

Response to treatment was categorized as improvement (assigned a value of 2), no progression (assigned a value of 1), and progression (assigned a value of 0).

Response was significantly better in the EN group (1.4 +/- 0.8) compared with the placebo group (0.3 +/- 0.5).
These results suggest that EN treatment is beneficial in dogs with naturally occurring idiopathic GN.

Source: Grauer GF,et al (2000): Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis. In: J Vet Intern Med 2000 Sep-Oct;14(5):526-33




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SMALL ANIMAL PRACTICE

In vivo confocal microscopy for diagnosis and therapy control of canine fungal keratitis
Is in vivo confocal microscopy a reliable method to perform a minimal invasive diagnosis and monitor the therapeutic response? A fascinating idea! This recently online published study describes in vivo corneal confocal microscopy of dogs during the clinical course of fungal keratitis and correlates findings with clinical evaluations and an ex vivo experimental canine fungal keratitis model. Seven dogs with naturally acquired fungal keratitis and ex vivo canine corneas experimentally infected with clinical fungal isolates were enrolled.

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