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Enalapril versus placebo in canine idiopathic glomerulonephritis
Enalapril is a well-known blocker of the ACE system in dogs and cats. Is it also effective in the therapy of naturally occurring, idiopathic glomerulonephritis in dogs?

Twenty-nine adult dogs were included in a blinded, multicenter, prospective clinical trial with membranous (n = 16) and membranoproliferative (n = 13).

Dogs were randomly assigned to receive either EN (0.5 mg/kg PO q12-24h; n = 16) or placebo (n = 14) for 6 months (1 dog was treated first with the placebo and then with EN). All dogs were treated with low-dose aspirin (0.5-5 mg/kg PO q12-24h) and fed a commercial diet. At baseline, serum creatinine (SrCr), systolic blood pressure (SBP), and glomerular histologic grade were not different between groups, but the urine protein/creatinine ratio (UP/C) was greater in the EN group compared with the placebo group (8.7 +/- 4.4 versus 4.7 +/- 2.3).
After 6 months of treatment, the change in UP/C from baseline was significantly different between groups (EN = -4.2 +/- 1.4 versus 1.9 +/- 0.9 in the placebo group). When data were adjusted for changes in SrCr (SrCr X UP/C) a similar significant reduction was noted ( 2.2 +/- 15.2 versus 8.4 +/- 10.1). The change in SBP after 6 months of treatment also was significantly different between groups (EN = -12.8 +/- 27.3 versus 5.9 +/- 21.5 mm Hg in the placebo group).

Response to treatment was categorized as improvement (assigned a value of 2), no progression (assigned a value of 1), and progression (assigned a value of 0).

Response was significantly better in the EN group (1.4 +/- 0.8) compared with the placebo group (0.3 +/- 0.5).
These results suggest that EN treatment is beneficial in dogs with naturally occurring idiopathic GN.

Source: Grauer GF,et al (2000): Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis. In: J Vet Intern Med 2000 Sep-Oct;14(5):526-33




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SMALL ANIMAL PRACTICE

Equine glaucoma - histopathologic findings
This recently published study from The Ohio State University characterizes and describes the histopathologic findings in equine globes enucleated due to glaucoma. Signalment, history, and treatment data were collected, and histologic slides of enucleated globes were examined and lesions recorded. 23 eyes from 23 horses were eligible for inclusion in this study.


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