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Enalapril versus placebo in canine idiopathic glomerulonephritis
Enalapril is a well-known blocker of the ACE system in dogs and cats. Is it also effective in the therapy of naturally occurring, idiopathic glomerulonephritis in dogs?

Twenty-nine adult dogs were included in a blinded, multicenter, prospective clinical trial with membranous (n = 16) and membranoproliferative (n = 13).

Dogs were randomly assigned to receive either EN (0.5 mg/kg PO q12-24h; n = 16) or placebo (n = 14) for 6 months (1 dog was treated first with the placebo and then with EN). All dogs were treated with low-dose aspirin (0.5-5 mg/kg PO q12-24h) and fed a commercial diet. At baseline, serum creatinine (SrCr), systolic blood pressure (SBP), and glomerular histologic grade were not different between groups, but the urine protein/creatinine ratio (UP/C) was greater in the EN group compared with the placebo group (8.7 +/- 4.4 versus 4.7 +/- 2.3).
After 6 months of treatment, the change in UP/C from baseline was significantly different between groups (EN = -4.2 +/- 1.4 versus 1.9 +/- 0.9 in the placebo group). When data were adjusted for changes in SrCr (SrCr X UP/C) a similar significant reduction was noted ( 2.2 +/- 15.2 versus 8.4 +/- 10.1). The change in SBP after 6 months of treatment also was significantly different between groups (EN = -12.8 +/- 27.3 versus 5.9 +/- 21.5 mm Hg in the placebo group).

Response to treatment was categorized as improvement (assigned a value of 2), no progression (assigned a value of 1), and progression (assigned a value of 0).

Response was significantly better in the EN group (1.4 +/- 0.8) compared with the placebo group (0.3 +/- 0.5).
These results suggest that EN treatment is beneficial in dogs with naturally occurring idiopathic GN.

Source: Grauer GF,et al (2000): Effects of enalapril versus placebo as a treatment for canine idiopathic glomerulonephritis. In: J Vet Intern Med 2000 Sep-Oct;14(5):526-33




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