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Promising novel drug for canine lymphoma
Lymphomas belong to the most common malignant multicentric neoplasias. A variety of chemotherapeutic protocols is currently recommended. In this study, 9-aminocamptothecin was used as a 72-h infusion with promising results.

A colloidal dispersion formulation of 9-aminocamptothecin (9-AC) was administered intravenously to 10 dogs with previously untreated, spontaneously occurring, multicentric lymphoma. The dogs received a 72-h infusion of 9-AC at a rate of 46.5-51.25 Āµg m2 h1 (total dose range 3.35-3.69 mg m2). This dose range was associated with myelosuppression, consisting principally of neutropenia with a nadir at 7 days following the start of infusion.

Neutropenia and thrombocytopenia were the most common toxicoses and are most likely to be dose-limiting toxicities; low-grade gastrointestinal signs were rarely seen. Concentrations of 9-AC lactone, as well as clinical toxicities, compare favourably with those found in humans.

Tumour responses were seen in all treated dogs. Response to other chemotherapy, following cessation of 9-AC treatment, was not obviously compromised even in dogs clinically resistant to 9-AC. 9-AC is a novel treatment drug for canine lymphoma, which appears to show great promise.

Source: Moore, A. S., Imondi, A. R., de Souza, P. L. & Wood, C. A. (2003): Intravenous administration of 9-aminocamptothecin to dogs with lymphoma. In: Veterinary and Comparative Oncology 1 (2), 86-93.




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SMALL ANIMAL PRACTICE

Toceranib phosphate (PalladiaĀ®) in canine gastrointestinal stromal tumorsmembers
Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. Highā€risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. This recently online published study reviews cases of toceranib phosphate use in dogs with GISTs and provides initial assessment of possible biological activity. A secondary aim was to evaluate patient and tumor characteristics for possible prognostic value.

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