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Feline plasma cell pododermatitis: case studies
Feline plasma cell pododermatitis is one of the poorly understood diseases in cats. Portuguese colleagues tried to study them histologically, histochemically and immunhistochemically and to compare the therapies used.

Eight cases of feline plasma cell pododermatitis, collected over a 3-year period, were studied using histological (haematoxylin and eosin), histochemical (methyl green-pyronin) and immunohistochemical (antibody against lambda light chains of immunoglobulins) techniques. No sex, breed or age predisposition, or paw predilection was observed.

The disease began as a swelling of the footpads, followed by ulceration. Histologically, lesions were characterized by the presence of a large number of plasma cells in a predominantly perivascular pattern. Binucleated plasma cells and mitotic figures were observed.

Clinical follow-up for over 1 year revealed total remission of the lesions both after glucocorticoid therapy in four cases, and total surgical excision in two animals. Follow-up studies were not possible in one case.

Source: Dias Pereira, Patrícia, Faustino, Augusto M. R. (2003): Feline plasma cell pododermatitis: a study of 8 cases. In: Veterinary Dermatology 14 (6), 333-337.




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SMALL ANIMAL PRACTICE

Toceranib phosphate (Palladia®) in canine gastrointestinal stromal tumorsmembers
Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. High‐risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. This recently online published study reviews cases of toceranib phosphate use in dogs with GISTs and provides initial assessment of possible biological activity. A secondary aim was to evaluate patient and tumor characteristics for possible prognostic value.

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