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First Description of Collagenofibrotic Glomerulonephropathy with Fibronectin Deposition in a Dog
Collagenofibrotic glomerulonephropathy is well-described in humans but has not been reported in a non-human species before this Shiba Inu which has been presented with severe proteinuria. A very interesting case report from Japan!

We report herein a case of collagenofibrotic glomerulonephropathy in a 3-year-old Shiba Inu with severe proteinuria.

Histologically, renal glomeruli were enlarged with massive deposition of a homogeneous eosinophilic substance within the mesangium and capillary walls.

The deposits reacted weakly with periodic acid–Schiff, stained deep blue with Masson`s trichrome, and were positive by immunofluorescence for type III collagen and fibronectin.

Ultrastructurally, the deposits consisted of fibrils and amorphous material in the mesangial matrix and beneath the glomerular capillary endothelium.

The fibrils had transverse bands analogous to those of collagen fibrils. Electron microscopy also revealed focal detachment of podocytes and foot process effacement in glomerular tufts, which suggested that podocyte injury had contributed to the development of proteinuria in this dog.

The current case resembles collagenofibrotic glomerulonephropathy (CFGN) in humans in histopathologic, immunofluorescence, and electron microscopic findings.

This is the first report of CFGN in a nonhuman species with glomerular deposition of fibronectin and type III collagen.


Source: J. Kamiie, K. Yasuno, K. Ogihara, A. Nakamura, S. Tamahara, Y. Fujino, K. Ono and K. Shirota (2009): Collagenofibrotic Glomerulonephropathy with Fibronectin Deposition in a Dog. In: Vet Pathol 46:688-692 (2009)




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SMALL ANIMAL PRACTICE

Variability of SDMA in apparently healthy dogsmembers
Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population‐based reference intervals. The objectives of this study were to determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs.

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