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Effects of aspirin in the upper gastrointestinal tract of dogs
Bayer 1885.jpg Picture: © Bayer Animal Health
Aspirin is one of the most popular drugs in humans and also sometimes given to dogs. Is there a significant effect to the upper gastrointestinal mucosa in dogs as known from humans? A group from Japan did an interesting study with endoscopic controls over 28 days.

Fifteen healthy castrated male dogs were included in the study. They were separated into three treatment groups that were administered etodolac, aspirin and a placebo orally, respectively. All treatments were continued for 28 days.

The animals were examined endoscopically on days 0, 3, 7, 10, 14, 17, 21. 24 and 28.

There were no gastrointestinal mucosal lesions in either the etodolac or the placebo group, whereas some gastric lesions developed in the aspirin group after day 17.

We considered that etodolac could be used for long-term treatments in dogs with fewer side-effects on the gastric mucosa than aspirin.

Source: K Nishihara, H Kikuchi, T Kanno, S Tanabe, T Sarashina, Y Uzuka (2001): Comparison of the upper gastrointestinal effects of etodolac and aspirin in healthy dogs. In: Journal of Veterinary Medical Science, 2001, Vol 63, Iss 10, pp 1131-1133



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SMALL ANIMAL PRACTICE

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