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Fipronil spray in canine scabies
A variety of drugs is known to be effective in canine scabies. A group from Greece did a field trial with fipronil spray which was used on a weekly basis (manufacturers´ recommendation: every 4-12 weeks) to evaluate if it was effective against Sarcoptes scabiei variatio canis.

Twelve dogs naturally infested with S. Scabiei were included in the trial. Diagnosis was based on clinical signs, skin scrapings and/or serology.

All the dogs were treated with a 0.25% fipronil spray, once weekly, for four consecutive weeks, using a total of 12 to 39 mL/kg of spray.

Pruritus and skin lesions disappeared, respectively, seven to 66 days and 14-71 days after the beginning of the treatment.

No relapses occurred during the three to four-month follow-up period.

Three dogs were kept under observation for a further eight to 12-month period with no relapses witnessed.
Of the nine dogs that had been seropositive at the beginning of the study, only two out of six were found to be seronegative when retested three to four months after the end of the treatment.


Source: AF Koutinas, MN Saridomichelakis, N Soubasis, S Bornstein, CK Koutinas (2001): Treatment of canine sarcoptic mange with fipronil spray: A field trial. In: Australian Veterinary Practitioner, 2001, Vol 31, Iss 3, pp 115+




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SMALL ANIMAL PRACTICE

The expression of Vitamin D receptors in dogs
There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog.
The objectives of this recently online published study were to define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine.

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