|Mitral valve regurgitation (MR) causes increased left atrial pressure (LAP) and is associated with occurrence of clinical signs. It will be useful to understand diurnal variations of LAP for the management and the better diagnosis of MR.
Circulatory parameters and diurnal rhythm might be linked to clinical signs in cardiac diseases. LAP may also exhibit a diurnal rhythm in dogs with MR.
Five healthy Beagle dogs weighing 9.8Â–12.8 kg (3 males and 2 females; aged 2 years) were used in this study, and a radiotelemetry system for continuous measurement of LAP was used in this study after the rupture of the chordae tendineae was experimentally induced via left atriotomy, and a transmitter catheter was inserted into the left atrium.
The body of the transmitter was implanted SC.
After clinical condition was stabilized, the severity of MR was evaluated by echocardiography, and LAP was recorded for 72 consecutive hours for the analysis of diurnal variation.
Results: Abrupt increases in LAP, which averaged 16.7 mmHg, were observed at feeding periods. In contrast, strong diurnal LAP variations were found, with a significant but slight increase in daytime LAP compared with nighttime LAP.
Conclusions and Clinical Importance: Diurnal LAP is characterized by a slight but significant nocturnal decrease and abrupt increases in response to excitation.
The latter seemed to be more important considering the relationship with clinical manifestations. The clinical relevance of exercise restriction in the management of MR was acknowledged.
Source: T. Ishikawa, R. Tanaka, S. Suzuki, Y. Saida, A. Soda, R. Fukushima, Y. Yamane (2009): Daily Rhythms of Left Atrial Pressure in Beagle Dogs with Mitral Valve Regurgitation. In: Journal of Veterinary Internal Medicine
Volume 23 Issue 4, Pages 824 - 831
Published Online: 1 Jun 2009
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