Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Melan A as indicator for canine melanomas
Melanomas are commonly seen in dogs and can be highly malignant, if occurring in the oral mucosa. This study from the University of Missouri is performed on more than 300 dogs and gives interesting new insights concerning overrepresented breeds and also immunohistochemical markers for these tumors.

Diagnostic records from 338 canine oral melanomas in 338 dogs received at the Veterinary Medical Diagnostic Laboratory (1992-1999) were reviewed. Of these tumors, 122 plus an additional 7 metastatic melanomas of unknown origin were selected for clinical follow-up, histologic review, and immunohistochemistry.

Chow Chow, Golden Retriever, and Pekingese/Poodle mix breeds were overrepresented, whereas Boxer and German Shepherd breeds were underrepresented. There was no gender predisposition and the average age at presentation was 11.4 years.

Forty-nine dogs were euthanized due to recurrence or metastasis.
The average postsurgical survival time was 173 days.
The gingiva and the labial mucosa were the most common sites.

Most tumors were composed of either polygonal cells (27 cases, 20.9%), spindle cells (44 cases, 34.1%), or a mixture of the two (polygonal and spindle) (54 cases, 41.9%). Clear cell (3 cases, 2.3%) and adenoid/papillary (1 case, 0.8%) patterns were uncommon.

The metastases of 6/6 oral melanomas had morphologic and immunohistochemical features similar to those of the primary tumors.

Immunohistochemically, Melan A was detected in 113/122 oral (92.6%) and 5/7 (71.9%) metastatic melanomas. Only 4/163 nonmelanocytic tumors were focally and weakly positive for Melan A. Antibodies against vimentin, S100 protein, and neuron-specific enolase stained 129 (100%), 98 (76%), and 115 (89.1%) of 129 melanomas, respectively.
Antibodies against other melanocytic-associated antigens (tyrosinase, glycoprotein 100) did not yield adequate staining.

We conclude that Melan A is a specific and sensitive marker for canine melanomas.

Source: Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Pace LW, Fard A, Kottler SJ (2000): Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. In:
Vet Pathol 2000 Nov;37(6):597-608



Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Brachycephalic airway syndrome - differences between pugs and French bulldogs
Does the brachycephalic airway syndrome mean the same in all brachycephalic breeds or are there breed-specific differences? A fascinating question was raised. This retrospective study including 72 dogs aimed to compare clinical features of brachycephalic airway syndrome and long-term surgical outcomes between pugs and French bulldogs and evaluate the influence of laryngeal collapse.

  • Prognostic factors in cats with HCMmembers
  • Ureteral Papilla Implantation in Cats Undergoing Renal Transplantationmembers
  • Storage lesion in canine packed erythrocytesmembers
  • Drug-induced infiltrative lung disease with cytarabine and prednisonemembers
  • Laparoscopic-assisted Gastropexy and the Gastrointestinal Transit Time in Dogsmembers
  • Transpalpebral ultrasonographic evaluation and measurement of the optic nerve members
  • Squamous cell carcinoma mimicking orbital myofibroblastic sarcomamembers
  • Unusual case of feline acute corneal hydropsmembers
  • Shock index in identifying acute blood loss in healthy dogsmembers
  • Correlation of direct in-house cerebrospinal fluid cytology with commercial pathology results members
  • 3 Serological Tests for Early Detection Of Leptospira-specific Antibodies members
  • Patient-specific facemask to facilitate brain biopsymembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved