Home
http://www.virbac.fr/ http://www.boehringer-ingelheim.com/ http://www.novartis.com/ http://www.animalhealth.bayerhealthcare.com/
vetcontact
Vetrinär
Tiermedizin
  WELCOME  
vetcontact
Vetrinär
Tiermedizin
  Home  
  Login / Newsletter  
vetcontact
Vetrinär
Tiermedizin
  CONTACTS  
vetcontact
Vetrinär
Tiermedizin
  Classifieds  
  New Products  
  VetCompanies  
  VetSchools  
vetcontact
Vetrinär
Tiermedizin
  PROFESSION  
vetcontact
Vetrinär
Tiermedizin
  Edutainment  
  VetAgenda  
  Presentations  
  Posters  
  ESAVS  
  Specialisation  
vetcontact
Vetrinär
Tiermedizin
  INSIGHT  
vetcontact
Vetrinär
Tiermedizin
  Congress News  
  Picture Galleries  
vetcontact
Vetrinär
Tiermedizin
  PRODUCTS  
vetcontact
Vetrinär
Tiermedizin
  Bayer  
  Boehringer Ing.  
  Novartis  
  Virbac

 
  Simply book for less...  
    

Bovine    Equine    Small Animal Practice    Swine Practice    Articles    Vetjournal    
deutsch english español polski francais
Home / WELCOME / Archiv / Small Animal Practice /     
 
Melan A as indicator for canine melanomas
Melanomas are commonly seen in dogs and can be highly malignant, if occurring in the oral mucosa. This study from the University of Missouri is performed on more than 300 dogs and gives interesting new insights concerning overrepresented breeds and also immunohistochemical markers for these tumors.

Diagnostic records from 338 canine oral melanomas in 338 dogs received at the Veterinary Medical Diagnostic Laboratory (1992-1999) were reviewed. Of these tumors, 122 plus an additional 7 metastatic melanomas of unknown origin were selected for clinical follow-up, histologic review, and immunohistochemistry.

Chow Chow, Golden Retriever, and Pekingese/Poodle mix breeds were overrepresented, whereas Boxer and German Shepherd breeds were underrepresented. There was no gender predisposition and the average age at presentation was 11.4 years.

Forty-nine dogs were euthanized due to recurrence or metastasis.
The average postsurgical survival time was 173 days.
The gingiva and the labial mucosa were the most common sites.

Most tumors were composed of either polygonal cells (27 cases, 20.9%), spindle cells (44 cases, 34.1%), or a mixture of the two (polygonal and spindle) (54 cases, 41.9%). Clear cell (3 cases, 2.3%) and adenoid/papillary (1 case, 0.8%) patterns were uncommon.

The metastases of 6/6 oral melanomas had morphologic and immunohistochemical features similar to those of the primary tumors.

Immunohistochemically, Melan A was detected in 113/122 oral (92.6%) and 5/7 (71.9%) metastatic melanomas. Only 4/163 nonmelanocytic tumors were focally and weakly positive for Melan A. Antibodies against vimentin, S100 protein, and neuron-specific enolase stained 129 (100%), 98 (76%), and 115 (89.1%) of 129 melanomas, respectively.
Antibodies against other melanocytic-associated antigens (tyrosinase, glycoprotein 100) did not yield adequate staining.

We conclude that Melan A is a specific and sensitive marker for canine melanomas.

Source: Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Pace LW, Fard A, Kottler SJ (2000): Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. In:
Vet Pathol 2000 Nov;37(6):597-608



Tell a friend   |   Print version   |   Send this article

SMALL ANIMAL PRACTICE

Oral extended release hydrocodone as analgesia after TPLOmembers
Tibial plateau leveling osteotomy (TPLO) is a very popular technique to treat ruptured cranial cruciate ligaments in dogs, and it requires a balanced analgesia regimen after surgery. The aim of this study was to determine the efficacy of oral extended‐release hydrocodone compared with oral firocoxib for analgesia following tibial plateau leveling osteotomy surgery in dogs in a hospital setting.

  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members
  • Phosphorus and protein supply before diagnosis of chronic kidney disease members
  • Bilateral retinoschisis in a Labrador retrievermembers
  • Water requirements of canine athletes during exercise over daysmembers
  • Predictors of Sudden Cardiac Death in Doberman Pinschers with DCMmembers
  • D-dimer concentration after soft tissue and orthopedic surgery members
  • Canine oral mucosa as autograft in unresponsive keratoconjunctivitis siccamembers
  • Computed tomographic findings in dogs infected with Crenosoma vulpismembers
  • Predicting histopathological classification of canine mammary carcinomas via sonographymembers
  • The expression of Vitamin D receptors in dogsmembers
  • Complex atlanto-axial malformation in a rabbitmembers


  • [ Home ] [ About ] [ Contact / Request ][ Disclaimer ]

    Copyright © 2001-2016 VetContact GmbH
    All rights reserved