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Efficacy of various antibiotics to treat feline chlamydia psittaci infection
Chlamydia psittaci is known to cause eye and respiratory infections in cats. Different therapeutic recommendations are given, but which is the most effective? This study compares the efficacy of amoxycillin-clavulanic-acid, doxycyclin and placebo in SPF cats.

Twenty-four specific pathogen-free cats were inoculated with 3 x 103 infectious units of a field isolate of Chlamydia psittaci on to the corneal surface. Seven days later they were assigned randomly to three groups of eight and treated orally for 19 days with either clavulanic
acid-potentiated amoxycillin, doxycycline or a placebo.

Both treated groups responded rapidly, with a marked reduction in isolation rates and clinical scores which were significantly lower than in the placebo group within two and four days, respectively.

After two days the group treated with potentiated amoxycillin had a significantly lower isolation score than the group treated with doxycycline.

Forty days after they were infected the clinical signs recurred in five of the eight cats treated with potentiated amoxycillin, but a four-week course of potentiated amoxycillin resulted in a complete clinical recovery with no evidence of a recurrence for six months.


Source: C. P. Sturgess, T. J. Gruffydd-Jones,D. A. Harbour, R. L. Jones (2001): Controlled study of the efficacy of clavulanic acid-potentiated amoxycillin in the treatment of Chlamydia psittaci in cats. In: Vet Record Volume 149 Number 3 Pages 73-76 21st July 2001



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SMALL ANIMAL PRACTICE

Proteasome inhibitors for canine and human osteosarcomamembers
Osteosarcoma, a common malignancy in large dog breeds, typically metastasises from long bones to lungs and is usually fatal within 1 to 2 years of diagnosis. Better therapies are needed for canine patients and their human counterparts, a third of whom die within 5 years of diagnosis. The authors compared the in vitro sensitivity of canine osteosarcoma cells derived from 4 tumours to the currently used chemotherapy drugs doxorubicin and carboplatin, and 4 new anti‐cancer drugs.

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