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Topically applied liposome-bound tetracycline in the treatment of dry eye model
Dry eyes are commonly seen in certain dog breeds, and currently they are treated with immunmodulatory products and/or tear substitutes. In this new study, the effects of liposome-bound tetracycline eye drops in a rabbit dry eye model evaluated if they were less allergic, preservative free and of prolonged action compared with other tear substitutes.

New Zealand albino rabbits were equally divided into control group and dry eye induced groups. Dryness was induced in 24 eyes of 12 healthy

adult male albino rabbits by instilling atropine sulfate eye drops 1% three times daily for 1 week, then animals were subdivided into four groups; group 1 (rabbits with dry eye model), groups 2, 3, and 4: rabbits with dry eye model treated for 7 days starting on 7th day of dryness induction with either tetracycline, empty liposome, or combined tetracycline with liposome as topical eye drops respectively.

Schirmer (STT) test and tear break up time (TBUT) were assessed on days 0, 2, 4, 7, 9, 11, and 14.

Animals were sacrificed on day 14 and histopathological examination of the cornea and conjunctiva was performed.

Results  Tear break up time and STT test values were significantly improved in groups 2, 3, 4 as compared with group 1.

The histopathological examination showed normal cytoarchitecture of corneas and conjunctivae in groups 2, 3, 4 against the dryness effect that continued to affect the cornea and conjunctival epithelium in group 1.

There was a significant improvement in the group treated with liposome-bound tetracycline eye drops (group 4) as compared with tetracycline alone (group 2) and empty liposome (group 3).

Conclusion:  The use of liposome encapsulated tetracycline significantly improved STT and TBUT values as well as reverse surface ocular pathology.

Source: Shafaa, M. W., El shazly, L. H., El shazly, A. H., El gohary, A. A. and El hossary, G. G. (2011), Efficacy of topically applied liposome-bound tetracycline in the treatment of dry eye model. Veterinary Ophthalmology, 14: 18–25. doi: 10.1111/j.1463-5224.2010.00834.x



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SMALL ANIMAL PRACTICE

Sonography vs percutaneous palpation to identify targeted thoracolumbar intervertebral disc spacesmembers
During minimally invasive spinal surgery, correct identification of the affected intervertebral disc space is critical. Percutaneous palpation is commonly used, but results may be unreliable. Fluoroscopy is the gold standard but can be cumbersome and exposes operators to ionizing radiation. Spinal ultrasound has been described in veterinary medicine and could be a feasible alternative. This prospective, methods comparison study mimicked a minimally invasive spinal surgery in 10 canine cadavers and compared the accuracy of ultrasound and percutaneous palpation for thoracolumbar intervertebral disc space identification, using fluoroscopy as the reference standard.

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  • Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillationmembers
  • Tick-borne relapsing fever in various speciesmembers
  • Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality members
  • Intracameral injection of epinephrine and 2% lidocaine in the eyes of healthy catsmembers


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