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Felbamate in partial epileptiform seizures of dogs
Partial seizures are sometimes seen in dogs raising the question if these animals should be treated with the `normal` antiepileptic drugs like phenobarbital or if an alternative should be tried, e.g. felbamate.

Six dogs with partial seizures or partial seizure-like activity were treated with the antiepileptic drug felbamate between 1993 and 1998. All dogs had a history and results of diagnostic testing suggestive of either primary (idiopathic) or occult secondary epilepsy. Dogs ranged between four months and eight years of age at the onset of seizure activity.

The median time period between onset of the first seizure and the start of felbamate therapy was 3.8 months (range 0.75 to 36 months).
Median duration of therapy was nine months (range two to 22 months).

All dogs experienced a reduction in seizure frequency after felbamate administration. Median total number of seizures post-treatment was two (range 0 to 9).
Two dogs had an immediate and prolonged cessation of seizure activity. Steady-state trough serum felbamate concentrations measured at two weeks, and one, 12 and 22 months after the commencement of therapy in four dogs ranged between 13 and 55 mg/litre (median 35 mg/litre).

Reversible haematological adverse effects were detected in two dogs, with one dog developing concurrent keratoconjunctivitis sicca.

These results suggest that felbamate can be an effective antiepileptic drug without life-threatening complications when used as monotherapy for partial seizures in the dog.

Source: Ruehlmann, M. Podell, P. March (2001): Treatment of partial seizures and seizure-like activity with felbamate in six dogs. In: Journal of Small Animal Practice (2001) 42, 403-408




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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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