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Multiantigenic vaccine against tick-transmitted Lyme disease in dogs
With the beginning of spring, the `tick season` starts. Many owners want to protect their animals from Lyme disease and ask for protection and for vaccination. How effective is this multiantigenic vaccine? This question is answered by a study performed at the University of Leipzig, Germany.

In an effort to develop a safe and effective vaccine for the prevention of Lyme borreliosis that addresses concerns raised over currently available vaccines, dogs were vaccinated twice with a multiantigenic preparation of Borrelia burgdorferi, strain N40, on days 0 and 20 of the experiment.

About 70 and 154 days after the first immunization, dogs were challenged by exposing them to field-collected Ixodes scapularis ticks harboring B. burgdorferi.

Vaccinated dogs were completely protected from infection by all criteria utilized to assess infection,developed high-titer anti-B. burgdorferi serum antibodies and growth inhibitory activity which persisted for over 200 days, and did not demonstrate any untoward consequence of vaccination.

Serum absorption experiments revealed that borreliacidal and most likely protective antibodies in dogs receiving the multiantigenic preparation were not only elicited against the OspA antigen, but were also produced against additional yet to be determined targets on B. burgdorferi organisms.

These data demonstrate that a multiantigenic vaccine is effective in preventing Lyme disease transmitted via the natural vector.

Source: R K. Straubinger , T. D Rao , E Davidson , B A. Summers , R H. Jacobson, A B. Frey (2001): Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine. In: Vaccine, Vol. 20 (1-2) (2001) pp. 181-193






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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breedâ€specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breedâ€specific RIs, where appropriate.

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