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New therapy of canine cutaneous mast cell tumors
Chemotherapy of mast cell tumors is currently done either with a prednisolone-cimetidine or lomustine-prednisolone-combination. In this article, another promising protocol especially fot localized mast cell tumors that are likely to recur owing to inadequate excision is described.

27 dogs with inadequately excised cutaneous mast cell tumors were treated with a combination from vinblastine and prednisolone.

20 dogs which were available for a follow-up one year later: 14 dogs showed no mast cell tumors, One dog showed local recurrence, four dogs had new tumors and one dog showed both.

There was no tumor-related mortality in all dogs. Although toxicity from the chemotherapy was generally mild, one dog dies of sepsis during treatment.

Source: Davies DR, Wyatt KM, Jardine JE et al (2004): `Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors`. In: JAAHA Vol. 40 No. 2 pp 124-130


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SMALL ANIMAL PRACTICE

Radiation Therapy for the Treatment of Sialocele in Dogs
Sialocele is a collection of saliva that has leaked from a damaged salivary gland or duct and is surrounded by granulation tissue. Surgery is the recognized first-line treatment. Recurrence rate after surgery is 5–14%. Salivary gland tissue is very sensitive to radiation therapy - so the aim of this new study was to characterize response rate and clinical course of dogs with sialocele treated with RT and to determine a starting dose for clinical use.

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