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New therapy of canine cutaneous mast cell tumors
Chemotherapy of mast cell tumors is currently done either with a prednisolone-cimetidine or lomustine-prednisolone-combination. In this article, another promising protocol especially fot localized mast cell tumors that are likely to recur owing to inadequate excision is described.

27 dogs with inadequately excised cutaneous mast cell tumors were treated with a combination from vinblastine and prednisolone.

20 dogs which were available for a follow-up one year later: 14 dogs showed no mast cell tumors, One dog showed local recurrence, four dogs had new tumors and one dog showed both.

There was no tumor-related mortality in all dogs. Although toxicity from the chemotherapy was generally mild, one dog dies of sepsis during treatment.

Source: Davies DR, Wyatt KM, Jardine JE et al (2004): `Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors`. In: JAAHA Vol. 40 No. 2 pp 124-130


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SMALL ANIMAL PRACTICE

Bioavailability of suppository acetaminophen in dogsmembers
Does acetaminophen reach a satisfactory biovailability in dogs? An interesting question! This recently published study enrolling healthy and ill animals determines the plasma pharmacokinetics of suppository acetaminophen (APAP). Six healthy client‐owned and 20 clinically ill hospitalized dogs were included in this prospective study.

  • Computed tomographic lymphography for lymph node staging in dogs with malignant tumors members
  • Characterization of ocular melanosis-affected canine melanocytesmembers
  • Nasopharyngeal sialoceles in brachycephalic dogsmembers
  • Enterococcus faecium SF68 on serum cobalamin and folate concentrationsmembers
  • Gastrointestinal eosinophilic sclerosing fibroplasia limited to the mesentery in a catmembers
  • Ion acid-base disturbances and associated mortality in dogsmembers
  • First description of ultrasonic bone curette in canine otic surgerymembers
  • Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
  • Oral extended release hydrocodone as analgesia after TPLOmembers
  • 25OH vitamin D3 serum concentration in dogs with acute polyradiculoneuritismembers
  • Type 1 immune mediated polyarthritis in dogs and temporal relationship to vaccination members
  • Phosphorus and protein supply before diagnosis of chronic kidney disease members


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