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Uveodermatologic syndrome in a non predisposed breed
Uveodermatologic syndrome (Vogt-Koyanagi-Harada-like syndrome) is an autoimmune disease affecting the melanocytes of both skin and eyes. It is described to occur in certain predisposed breeds like Akita Inu, Samoyed etc. This is the first documented case in another breed, the Brazilian Fila.

A 5-year-old Brazilian Fila dog was presented with a history of vision loss, alopecia, and generalized depigmentation of the skin and hair.

Clinical examination confirmed generalized depigmentation and pyoderma.
On ophthalmic examination there was depigmentation at the eyelid mucocutaneous junction, associated with anterior uveitis, and bilateral posterior synechia at 360°.

Both the complete blood count and skin scraping were normal. Skin biopsy showed histiocytary lichenoid interface dermatitis with an absence of pigment within the keratinocytes, and a moderate lymphomononuclear infiltrate and predominance of histiocytes in the papilar derma suggestive of uveodermatologic syndrome.

Clinical management consisted of oral and topical administration of prednisone, associated with 1% indometacine eye drops. Methylprednisone was also used twice via the subconjunctival route, at an interval of 15 days.

To prevent the development of secondary glaucoma due to posterior synechiae, dorzolamide and timolol eye drops were indicated.
Both dermatologic and ophthalmic signs showed good improvement, vision was preserved, and some repigmentation of the skin and hair occurred.

Source: Laus, José L., Sousa, Marlos G., Cabral, Vânia P., Mamede, Fabrício V. & Tinucci-Costa, Mirela (2004): Uveodermatologic syndrome in a Brazilian Fila dog. In: Veterinary Ophthalmology 7 (3), 193-196.




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SMALL ANIMAL PRACTICE

Microbiota of traumatic, open fracture wounds and the mechanism of injury
Open fractures are characterized by disruption of the skin and soft tissue, which allows for microbial contamination and colonization. Preventing infection‐related complications of open fractures and other acute wounds remains an evolving challenge due to an incomplete understanding of how microbial colonization and contamination influence healing and outcomes. Culture‐independent molecular methods are now widely used to study human‐associated microbial communities without introducing culture biases. This recently online published study describes the fascinating association between the mechanism of injury and the microbiota of the wounds.

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