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Prostate cancer - higher risk for castrated dogs?
Iff_peterscollection.jpg Picture: © Dr. Stefanie Peters
In many small animal practices, owners are recommended to have male dogs castrated also because of the decreased risk to develop prostate cancer. This study performed on 70 dogs with prostate cancer shows opposite results!

The purpose of this study was to characterize canine prostate cancer using immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate these results with the dogs` castration status/castration time.

Seventy dogs with prostate cancer were included, 71% were castrated and 29% were intact. Compared with an age-matched control population, castrated dogs were at increased risk of prostate cancer, odds ratio 3.9.
Immunohistochemical staining was performed on 58 cases. Forty-six of the 58 stained positive for cytokeratin 7 (CK 7) (ductal/urothelial origin) and one of the 58 stained positive for prostate-specific antigen. Dogs with CK 7-positive tumours were younger when castrated than dogs with CK 7-negative tumours, 2 versus 7 years (P = 0.03); dogs castrated at 2 years of age were more likely to be CK 7-positive (P = 0.009).

These results show that most canine prostatic carcinomas are of ductal/urothelial, androgen-independent origin. This is consistent with the epidemiological findings, showing increased risk in castrated dogs. Canine prostate cancer may, therefore, not be a realistic model for the human disease.

source: Sorenmo, K. U., Goldschmidt, M., Shofer, F., Goldkamp, C. & Ferracone, J. (2003)
Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.
Veterinary and Comparative Oncology 1 (1), 48-56.
doi: 10.1046/
j.1476-5829.2003.00007.x



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SMALL ANIMAL PRACTICE

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