The purpose of this study was to characterize canine prostate cancer using immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate these results with the dogs` castration status/castration time.
Seventy dogs with prostate cancer were included, 71% were castrated and 29% were intact. Compared with an age-matched control population, castrated dogs were at increased risk of prostate cancer, odds ratio 3.9.
Immunohistochemical staining was performed on 58 cases. Forty-six of the 58 stained positive for cytokeratin 7 (CK 7) (ductal/urothelial origin) and one of the 58 stained positive for prostate-specific antigen. Dogs with CK 7-positive tumours were younger when castrated than dogs with CK 7-negative tumours, 2 versus 7 years (P = 0.03); dogs castrated at 2 years of age were more likely to be CK 7-positive (P = 0.009).
These results show that most canine prostatic carcinomas are of ductal/urothelial, androgen-independent origin. This is consistent with the epidemiological findings, showing increased risk in castrated dogs. Canine prostate cancer may, therefore, not be a realistic model for the human disease.
source: Sorenmo, K. U., Goldschmidt, M., Shofer, F., Goldkamp, C. & Ferracone, J. (2003)
Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.
Veterinary and Comparative Oncology 1 (1), 48-56.
doi: 10.1046/
j.1476-5829.2003.00007.x
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