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Hereditary eye diseases in Miniature Schnauzers
Hereditary eye problems are described in many breeds. This new study about inherited retinal dysplasia and persistent hyperplastic primary vitreous in more than 100 Miniature Schnauzers gives an overview about clinical signs and etiology.

106 Miniature Schnauzers were examined, using a biomicroscope and indirect ophthalmoscope. The anterior and posterior segments of affected dogs were photographed. Four enucleated eyes were examined using routine light microscopy and scanning electron microscopy.

A pedigree was constructed and related dogs were test-bred to define the mode of inheritance of this syndrome. Congenital retinal dysplasia was confirmed in 24 of 106 related Miniature Schnauzer dogs.

Physical and postmortem examinations revealed that congenital abnormalities were limited to the eyes.

Biomicroscopic, indirect ophthalmoscopic, and neuro-ophthalmic examinations confirmed that some of these dogs were blind secondary to bilateral retinal dysplasia and detachment (nonattachment) (n = 13), and the remainder had generalized retinal dysplasia (n = 11). Fifteen of these dogs were also diagnosed with unilateral (n = 9) or bilateral (n = 6) persistent hyperplastic primary vitreous. Nutritional, infectious, or toxic etiologies were not evident on physical, postmortem, light microscopic, or transmitting and scanning electron microscopic examination of four affected Miniature Schnauzers.

We examined the pedigree and determined that an autosomal recessive mode of inheritance was most likely. Three test-bred litters including those from affected parents, carrier and affected parents, and carrier parents confirmed this mode of inheritance.

This study confirms that retinal dysplasia and persistent hyperplastic primary vitreous is a congenital abnormality that is inherited as an autosomal recessive condition in Miniature Schnauzers.


Source: Grahn, Bruce H., Storey, Eric S. & McMillan, Catherine (2004): Inherited retinal dysplasia and persistent hyperplastic primary vitreous in Miniature Schnauzer dogs. In: Veterinary Ophthalmology 7 (3), 151-158.




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