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Low tidal volume ventilation in healthy beagle dogs
Is low tidal volume (VT) ventilation really associated with the development of respiratory acidosis and changes in lung function in healthy dogs? An important question! This randomized prospective experimental cross-over study on 5 healthy beagle dogs was performed to answer this question.


Dogs were anesthetized and randomly mechanically ventilated with VT of 6, 8, 10, 12, and 15 mL/kg while maintaining a constant minute volume.

Arterial blood gases and pulmonary mechanics were collected after 15 minutes of equilibration at each VT.

Repeated measures ANOVA was used to determine the effect of VT with a P-value of <0.05 considered significant, and a Pearson product moment was used to determine correlation between VT and pH and PaCO2.

VT had a significant effect on PaCO2 (P < 0.001) and on pH (P < 0.001) with lower VT being associated with higher PaCO2 and lower pH.

There was a strong correlation between VT and PaCO2 (r = –0.87) and VT and pH (r = 0.83). Increased airway pressures and pulmonary compliance were associated with increasing VT.

Conclusions: There is a predictable decrease in the pH, decrease in airway pressure, decrease in compliance, and increase in the PaCO2 associated with lower VT.

Low VT ventilation is well tolerated in healthy dogs; the role of low VT ventilation in dogs with acute lung injury/acute respiratory distress syndrome as well as the influence of positive end expiratory pressure requires further evaluation.


Source: Oura, T., Rozanski, E. A., Buckley, G. and Bedenice, D. (2012), Low tidal volume ventilation in healthy dogs. Journal of Veterinary Emergency and Critical Care, 22: 368–371. doi: 10.1111/j.1476-4431.2012.00749.x




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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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