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VAC Protocol for Dogs with Stage III Hemangiosarcoma
Hemangiosarcomas (HSAs) are aggressive tumors with a high rate of metastasis. Clinical stage has been considered a negative prognostic factor for survival. The study authors hypothesized that the median survival time (MST) of dogs with metastatic (stage III) HSA treated with a vincristine, doxorubicin, and cyclophosphamide (VAC) chemotherapy protocol would not be different than those with stage I/II HSA. Is this correct?

Sixty-seven dogs with HSA in different anatomic locations were evaluated retrospectively.

All dogs received the VAC protocol as an adjuvant to surgery (n = 50), neoadjuvant (n = 3), or as the sole treatment modality (n = 14).

There was no significant difference (P = 0.97) between the MST of dogs with stage III and stage I/II HSA.

For dogs presenting with splenic HSA alone, there was no significant difference between the MST of dogs with stage III and stage I/II disease (P = 0.12).

The overall response rate (complete response [CR] and partial response [PR]) was 86%).

No unacceptable toxicities were observed.

Dogs with stage III HSA treated with the VAC protocol have a similar prognosis to dogs with stage I/II HSA.

Dogs with HSA and evidence of metastases at the time of diagnosis should not be denied treatment.



Source: Francisco J. Alvarez, Kenji Hosoya, Ana Lara-Garcia, William Kisseberth, Guillermo Couto (2013): VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma
In: Published online before print September 19, 2013, doi: 10.5326/JAAHA-MS-5954 Journal of the American Animal Hospital Association Nov/Dec 2013 jaaha.5954






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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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