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VAC Protocol for Dogs with Stage III Hemangiosarcoma
Hemangiosarcomas (HSAs) are aggressive tumors with a high rate of metastasis. Clinical stage has been considered a negative prognostic factor for survival. The study authors hypothesized that the median survival time (MST) of dogs with metastatic (stage III) HSA treated with a vincristine, doxorubicin, and cyclophosphamide (VAC) chemotherapy protocol would not be different than those with stage I/II HSA. Is this correct?

Sixty-seven dogs with HSA in different anatomic locations were evaluated retrospectively.

All dogs received the VAC protocol as an adjuvant to surgery (n = 50), neoadjuvant (n = 3), or as the sole treatment modality (n = 14).

There was no significant difference (P = 0.97) between the MST of dogs with stage III and stage I/II HSA.

For dogs presenting with splenic HSA alone, there was no significant difference between the MST of dogs with stage III and stage I/II disease (P = 0.12).

The overall response rate (complete response [CR] and partial response [PR]) was 86%).

No unacceptable toxicities were observed.

Dogs with stage III HSA treated with the VAC protocol have a similar prognosis to dogs with stage I/II HSA.

Dogs with HSA and evidence of metastases at the time of diagnosis should not be denied treatment.



Source: Francisco J. Alvarez, Kenji Hosoya, Ana Lara-Garcia, William Kisseberth, Guillermo Couto (2013): VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma
In: Published online before print September 19, 2013, doi: 10.5326/JAAHA-MS-5954 Journal of the American Animal Hospital Association Nov/Dec 2013 jaaha.5954






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SMALL ANIMAL PRACTICE

Staining hair samples with a modified Wright-Giemsa stain to diagnose feline dermatophytosismembers
Direct examination of the hair is a simple diagnostic test for the diagnosis of dermatophytosis; training is needed to use this test. This study tried to evaluate whether use of modified Wright–Giemsa blue stain and/or photographic images of infected and uninfected hairs improved the user`s ability to identify infected or uninfected hairs. Ten cats with, and 10 cats without, dermatophytosis due to Microsporum canis (n = 20) were enrolled.

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