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Oral recombinant vaccine in therapy-resistant oral papillomatosis
Oral papillomatosis in young dogs is a self-limiting disease in most cases. Surgery is recommended if no spontaneous resolution is seen. But what if both does not work? The use of subcutaneous vaccines is no longer recommended because of the risk of squameous cell carcinomas at the injection site. Does an oral vaccine work?

This report describes a 16-month-old female, otherwise seemingly healthy, Siberian husky dog with severe oral papillomatosis that did not regress spontaneously and was refractory to surgical treatment over a 6-month period.

Regression of the papillomas was achieved by administering a series of experimental vaccinations starting at the time of the last surgery.

The vaccine consisted of systemically administered canine oral papillomavirus major coat protein L1 that has been shown to self-assemble into virus-like particles. They cause a humoral response that has been shown to prevent the onset and development of papillomas.

In this case, however, following unsuccessful surgical treatment, the vaccine acted therapeutically, causing the papillomas that had regrown to shrink. No side-effects were noted.


Source: Kuntsi-Vaattovaara, H., Verstraete, F. J. M., Newsome, J. T. & Yuan, H. (2003): Resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papillomavirus vaccine. In. Veterinary and Comparative Oncology 1 (1), 57-63



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