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Bone marrow hypoplasia after fenbendazole administration in a dobermann
Dobermanns are known to be at risk to show adverse effects to certain drugs e.g. trimethoprime sulfonamides. In this case, a dog with fenbendazole-associated reversible bone marrow hypoplasia is described.

The 1,5 year-old Doberman Pinscher showed a sudden onset of fever and malaise twelve days after a therapy with fenbendazole because of a suspected lungworm infection had been initiated.

CBC of the patient revealed a pancytopenia and bone marrow biopsy showed bone marrow hypoplasia of undetermined origin.

After discontinuation of the fenbendazole, bactericidal antibiotics and fluid therapy a complete resolution of clinical and hematological abnormalities was seen within 15 days.

After exclusion of infectious, neoplastic, autoimmune and toxic etiologies and resolution of the signs after discontinuation of the fenbendazole the authors believe that an idiosyncratic reaction to fenbendazole caused the bone marrow hypoplasia.

Source: Gary AT et al (2004): Bone marrow hypoplasia associated with fenbendazole administration in a dog. In: JAAHA 40:3, pp 224-229


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