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Zonisamide in refractory canine epilepsy
Epilepsy in dogs and men can be very frustrating to control. Which choices are the best if the `normal` drugs like phenobarbital are not effective? Zonisamide, a sulfonamide-derivate, is an antiepileptic for focal and generalized epilepsy in men. It has also some positive effects in dogs.

12 dogs with poorly controlled primary epilepsy were included in this prospective non-comparative study. Oral zonisamide dose was adapted to the desired effective blood levels (10 to 40 ug/dl). The mean dose required was 8,9 mg/kg every 12 hours.

Seven dogs showed a favourable response with a mean reduction of the seizures of 81,3%. Five dogs unfortunately even showed an increased seizure frequency.

Mild side effects like transient sedation, vomiting and diarrhea were seen in 6 (50%) of the treated animals.

Source: Dewey CW, et al (2004): Zonisamide Therapy for Refractory Idiopathic Eiplepsy in Dogs. In: JAAHA 40:§, pp 270-284


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SMALL ANIMAL PRACTICE

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Gastric pneumatosis is an imaging finding defined as the presence of gas foci in the gastric wall. In humans, this imaging feature can result from one of two separate clinical entities: life‐threatening emphysematous gastritis or clinically benign gastric emphysema. This retrospective case series study describes the clinical and imaging features in five animals diagnosed with spontaneous gastric pneumatosis without gastric dilatation‐volvulus.

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