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Zonisamide in refractory canine epilepsy
Epilepsy in dogs and men can be very frustrating to control. Which choices are the best if the `normal` drugs like phenobarbital are not effective? Zonisamide, a sulfonamide-derivate, is an antiepileptic for focal and generalized epilepsy in men. It has also some positive effects in dogs.

12 dogs with poorly controlled primary epilepsy were included in this prospective non-comparative study. Oral zonisamide dose was adapted to the desired effective blood levels (10 to 40 ug/dl). The mean dose required was 8,9 mg/kg every 12 hours.

Seven dogs showed a favourable response with a mean reduction of the seizures of 81,3%. Five dogs unfortunately even showed an increased seizure frequency.

Mild side effects like transient sedation, vomiting and diarrhea were seen in 6 (50%) of the treated animals.

Source: Dewey CW, et al (2004): Zonisamide Therapy for Refractory Idiopathic Eiplepsy in Dogs. In: JAAHA 40:§, pp 270-284


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SMALL ANIMAL PRACTICE

Patient-specific facemask to facilitate brain biopsymembers
The objective of this pilot study was to describe the application and first preliminary data of a novel MRI and CT compatible patient-specific facemask for stereotactic brain biopsy of intracranial lesions in dogs. Five client-owned dogs presenting for neurological deficits consistent with forebrain disease were included in the study. All dogs had MRI findings consistent with an intracranial lesion. But biopsies in this region are not easy to obtain. Does an individual face mask help?

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  • RET-He to diagnose iron-deficient erythropoiesis in dogsmembers
  • Hypertriglyceridemia-Associated Proteinuria in Miniature Schnauzersmembers
  • Gastrointestinal dysmotility disorders in critically ill animalsmembers
  • Disorder of sex development in a cat with chromosome mosaicism members
  • Generalized discoid lupus erythematosus in dogs members
  • Epidermolysis bullosa acquisita in dogsmembers
  • Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogsmembers
  • Efficacy and Potential Complications of Transjugular Liver Biopsymembers
  • Hypomagnesemia in Brachycephalic Dogsmembers
  • Comparison of two minimally invasive techniques for liver biopsy members
  • Topical aqueous sirolimus and the tear production members


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