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Carmustine instead of cyclophosphamide in canine lymphoma
The combination of vincristine, prednisone and cyclophosphamide is one of most popular treatment protocols for canine malignant lymphoma. In this recently published study, cyclophosphamide was replaced by carmustine which is a nonphase-specific alkylating agent. Marked neutropenia was one of its main side effects.

Six of the seven dogs treated with the carmustine-vincristine-prednisone protocol achieved complete remission (85,7%), one a partial remission.

The median survival time was 224 days, the median duration of remission 183 days.

No significant alteration of the platelets and the erythrocytes and no abnormalities in biochemical profiles were noted during therapy. A marked neutropenia after carmustine application was observed.

Thus, carmustine is an effective alternative in the treatment of canine malignant lymphoma.

Source: Ricci Lucas SR et al (2004): Carmustine, vincristine and prednisone in the treatment of canine lymphosarcoma. In: JAAHA 40:§, pp 292-299


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SMALL ANIMAL PRACTICE

Reference intervals for blood parameters in Shetland Sheepdogsmembers
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.

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