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Carmustine instead of cyclophosphamide in canine lymphoma
The combination of vincristine, prednisone and cyclophosphamide is one of most popular treatment protocols for canine malignant lymphoma. In this recently published study, cyclophosphamide was replaced by carmustine which is a nonphase-specific alkylating agent. Marked neutropenia was one of its main side effects.

Six of the seven dogs treated with the carmustine-vincristine-prednisone protocol achieved complete remission (85,7%), one a partial remission.

The median survival time was 224 days, the median duration of remission 183 days.

No significant alteration of the platelets and the erythrocytes and no abnormalities in biochemical profiles were noted during therapy. A marked neutropenia after carmustine application was observed.

Thus, carmustine is an effective alternative in the treatment of canine malignant lymphoma.

Source: Ricci Lucas SR et al (2004): Carmustine, vincristine and prednisone in the treatment of canine lymphosarcoma. In: JAAHA 40:§, pp 292-299


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SMALL ANIMAL PRACTICE

Patient-specific facemask to facilitate brain biopsymembers
The objective of this pilot study was to describe the application and first preliminary data of a novel MRI and CT compatible patient-specific facemask for stereotactic brain biopsy of intracranial lesions in dogs. Five client-owned dogs presenting for neurological deficits consistent with forebrain disease were included in the study. All dogs had MRI findings consistent with an intracranial lesion. But biopsies in this region are not easy to obtain. Does an individual face mask help?

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  • Gastrointestinal dysmotility disorders in critically ill animalsmembers
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  • Epidermolysis bullosa acquisita in dogsmembers
  • Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogsmembers
  • Efficacy and Potential Complications of Transjugular Liver Biopsymembers
  • Hypomagnesemia in Brachycephalic Dogsmembers
  • Comparison of two minimally invasive techniques for liver biopsy members
  • Topical aqueous sirolimus and the tear production members
  • JAK 1/2 inhibitor in the treatment of canine B-cell lymphomamembers


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