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Repeated administration of propofol in dogs and cats
Propofol has become a very popular drug in small animal medicine and is considered to be a safe and well-tolerated option. But what happens if the drug is administered on consecutive days - is there an accumulation and thus a higher risk? This study on 10 dogs and 10 cats showed no apparent cumulative side effects.

The animals received a bolus of propofol i.v. at the dose of 6 mg/kg (dogs) and 10 mg/kg (cats) for three consecutive days.

The occurence of apnea, heart and respiratory rates, blood pressure, time to movement and biochemical profiles were recorded.

3 cats showed apnea, 6 cats showed a non-significant increase in the number of Heinz bodies.

Based on these results, the authors see no apparent cumulative adverse effects from a bolus of bisulfite-containing propofol, administered on three consecutive days.

Source: Matthews NS et al. (2004): Repetitive Propofol Administration in Dogs and Cats. In: JAAHA 40:4 pp 255-260


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