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Does orally administered hydrocortisone increase the intraocular pressure?
This interesting question was evaluated in a recently published study on 17 ocular normotensive dogs. The result: At least 3,3 mg/kg hydrocortisone p.o. given TID over 5 weeks does not increase the intraocular pressure in nonglaucomatous dogs!

The dogs were randomly assigned to treatment (n = 9) and control (n = 8) groups. Dogs in the treatment group received hydrocortisone, 3.3 mg/kg PO every 8 h, and dogs in the control group received gelatin capsule placebo PO every 8 h for 5 weeks.
Applanation tonometry was performed on both eyes of all dogs prior to treatment and then once weekly for 5 weeks during hydrocortisone treatment.

No significant effect of treatment was noted for right (P = 0.1013) or left (P = 0.1157) eyes during the treatment period, nor was there significant interaction of treatment by week for the right (P = 0.9456) or left (P = 0.3577) eyes.

A significant rise in IOP over the treatment period was noted in both right (P < 0.0001) and left (P = 0.0006) eyes of both groups, but was unrelated to treatment.

Orally administered hydrocortisone does not significantly increase IOP in nonglaucomatous dogs when administered over a 5-week period.



Source: Herring, Ian P., Herring, Erin S. & Ward, Daniel L. (2004): Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs. In: Veterinary Ophthalmology 7 (6), 381-384.




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