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Does orally administered hydrocortisone increase the intraocular pressure?
This interesting question was evaluated in a recently published study on 17 ocular normotensive dogs. The result: At least 3,3 mg/kg hydrocortisone p.o. given TID over 5 weeks does not increase the intraocular pressure in nonglaucomatous dogs!

The dogs were randomly assigned to treatment (n = 9) and control (n = 8) groups. Dogs in the treatment group received hydrocortisone, 3.3 mg/kg PO every 8 h, and dogs in the control group received gelatin capsule placebo PO every 8 h for 5 weeks.
Applanation tonometry was performed on both eyes of all dogs prior to treatment and then once weekly for 5 weeks during hydrocortisone treatment.

No significant effect of treatment was noted for right (P = 0.1013) or left (P = 0.1157) eyes during the treatment period, nor was there significant interaction of treatment by week for the right (P = 0.9456) or left (P = 0.3577) eyes.

A significant rise in IOP over the treatment period was noted in both right (P < 0.0001) and left (P = 0.0006) eyes of both groups, but was unrelated to treatment.

Orally administered hydrocortisone does not significantly increase IOP in nonglaucomatous dogs when administered over a 5-week period.



Source: Herring, Ian P., Herring, Erin S. & Ward, Daniel L. (2004): Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs. In: Veterinary Ophthalmology 7 (6), 381-384.




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SMALL ANIMAL PRACTICE

Aldosterone-producing adrenocortical carcinoma with myxoid differentiation in a Persian cat
A 10‐year‐old male neutered Persian cat was presented with an abdominal mass and history of weakness. Blood smear examination found marked elliptocytosis, and serum biochemical analysis revealed hypokalemia, hypochloremia, increased creatine kinase activity, and a high aldosterone concentration. Cytologic examination of the mass revealed neoplastic endocrine cells with moderate criteria of malignancy, favoring adrenocortical neoplasia. A very interesting case report!

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