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Clozapine intoxication in a dog
Clozapine is a tricyclic antidepressivum which is sometimes given in the dog. The signs of intoxication are various: one is hyperexcitation - very interesting!

Intoxication with clozapine in a dog, suspected from history and clinical signs at presentation, was confirmed by demonstration of decreasing serum levels of this drug.

Clozapine is a tricyclic dibenzodiazepine used for treatment of human schizophrenia, and clinical signs of intoxication in humans include tachycardia, seizures, muscle fasciculations, agitation, and sialorrhea.

This dog showed ptyalism, hyperthermia, tachycardia, and was easily excited by tactile or auditory stimulation.

The calculated peak concentration of clozapine in this dog was approximately 6,000 ng/mL, and the elimination half-life (t1/2) was 5 hours.

Charcoal administration and supportive care led to a successful outcome in this patient.


Source: Boel A. Fransson, Katrina A. Mealey, Sarah R. Dutta (2002): Clozapine Intoxication in a Dog. In: Journal of the American Animal Hospital Association 38:421-424 (2002)



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SMALL ANIMAL PRACTICE

Efficacy of three antiseptics as surgical skin preparations
Which of the three commonly used antiseptics is the most efficacious? This new prospective randomized clinical study compares the antimicrobial efficacy of a 2% chlorhexidine gluconate and 70% ethanol solution (CG+A) with that of F10 Skin Prep Solution (F10) and electrochemically activated water (EAW) when used as a surgical preparation in canine patients. The patients: 116 bitches presented for ovariohysterectomy.


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