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Clozapine intoxication in a dog
Clozapine is a tricyclic antidepressivum which is sometimes given in the dog. The signs of intoxication are various: one is hyperexcitation - very interesting!

Intoxication with clozapine in a dog, suspected from history and clinical signs at presentation, was confirmed by demonstration of decreasing serum levels of this drug.

Clozapine is a tricyclic dibenzodiazepine used for treatment of human schizophrenia, and clinical signs of intoxication in humans include tachycardia, seizures, muscle fasciculations, agitation, and sialorrhea.

This dog showed ptyalism, hyperthermia, tachycardia, and was easily excited by tactile or auditory stimulation.

The calculated peak concentration of clozapine in this dog was approximately 6,000 ng/mL, and the elimination half-life (t1/2) was 5 hours.

Charcoal administration and supportive care led to a successful outcome in this patient.


Source: Boel A. Fransson, Katrina A. Mealey, Sarah R. Dutta (2002): Clozapine Intoxication in a Dog. In: Journal of the American Animal Hospital Association 38:421-424 (2002)



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SMALL ANIMAL PRACTICE

3 Serological Tests for Early Detection Of Leptospira-specific Antibodies
Leptospirosis in dogs is a disease of global importance. Early detection and appropriate therapeutic intervention are necessary to resolve infection and prevent zoonotic transmission. However, its diagnosis is hindered by nonspecific clinical signs and lack of rapid diagnostic tests of early infection. Recently, 2 rapid point-of-care tests (WITNESS Lepto [WITNESS Lepto, Zoetis LLC, Kalamazoo, MI, USA] and SNAP Lepto [SNAP Lepto, IDEXX Laboratories, Westbrook, ME, USA]) for detection of Leptospira-specific antibodies in canine sera were developed. This recently online published article compares three systems for early diagnosis.

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